L1: Introduction to Therapeutics

Question 1

The difference between a therapeutic drug & a poison is…?

Answer 1

the dose rate

Question 2

What is therapeutics?

Answer 2

Treatment of disease

Question 3

What is pharmacology?

Answer 3

Study of drugs

Question 4

What is the biggest side effect of NSAIDS?

Answer 4

prevention of clotting

Question 5

Why do herbivores metabolise (clear) drugs more quickly than carnivores?

Answer 5

They are designed to eat a plant based diet, & most drugs originate from plants

Question 6

What is pharmacokinetics?

Answer 6

tracking the drug through the body

Question 7

What is pharmacodynamics?

Answer 7

What the drug does; only happens w/ certain []

Question 8

What range is needed for drug efficacy?

Answer 8

Therapeutic range of drug plasma concentrations

Question 9

What do in vitro dose response studies tell us?

Answer 9

What [] of drug is needed

Question 10

Pharmacokinetics is determined by ADME processes, which also determine plasma [] of drug over time.

Explain?

Answer 10

Question 11

List the principles of pharmacology

Answer 11

• Relationship b/w drug [] & biological response
• drug action over time
• factors affecting absorption, distribution, binding, metabolism & elimination
• Biological changes that result from repeated use: tolerance, addiction, adverse rxns, altered rates of metabolism
• Antagonism of effects of one drug by another
• receptor theory