Anti Inflammatories II Flashcards
1
Q
What is the MOA of glucocorticoids?
A
Inhibit Phospholipase A2, :: lowering Arachidonic Acid
– Suppress COX (1 & 2) and LOX synthesis
- :: < Prostaglandins and leukotrienes
- < Cell mediated immunity (CMI)
2
Q
What are the anti inflammatory effects of glucocorticoids?
A
- decreased CMI
- < pyrogenic respence to inflamm (breaks fever)
- decreased accumulation of macrophages at site of inflamm (chronic inflamm)
- > circulating neutrophils; < tissue neutrophils (hindering acute inflamm)
- *Anti inflamm stuff:**
- < vasodilation
- < tissue damage
- < formation of prostaglandins
3
Q
Are corticisteroids hormones?
A
yes
4
Q
List & describe the Glucocorticoid side effects
A
- *1. All the NSAID side effects (COX inhibition)**
- GIT ulceration
- kidney failure
- altered platelet function
- *2. Metabolic**
- suppression of hypothalamic - pituitary -adrenal axis (HPA axis)
- *3. Immune system**
- immunosuppression
- *4. Cardiovascular**
- hypertension
5
Q
Clincal symptoms of GLCD side effects
A
- COMMON:
polyuria/polydipsia
mood chnage
obesity
hair loss - SPORADIC:
peptic ulcers
cataracts
6
Q
Clinical applications of GLCD?
A
allergy
inflammation
immune disease
pulmonary disease
cardio
musculoskeletal
eye
GIT
etc
7
Q
Name some common GLCD
A
- prednisolone (oral, IV, topical)
- dexamethasone
- Neocort
- cortavance
