Intro to Therapeutics Flashcards
1
Q
What are the principals of pharmacology
A
- The relationship between drug concentration and biological response
- Drug action over time
- Factors affecting absorption, distribution, binding, metabolism and elimination of drugs
- Biological changes that result from repeated drug use: tolerance, addiction, adverse reactions, altered rates of metabolism etc
- Antagonism of the effects of one drug by another
- Receptor theory
2
Q
What drug concentrations are needed for efficacy?
A
The THERAPEUTIC RANGE of drug plasma concentrations
3
Q
what is Pharmacodynamics?
A
“What the drug does to the body”
4
Q
In vitro dose response studies tell us?
A
what concentration of drug is needed
5
Q
What determines pharmacokinetics?
A
The four processes of ADME determine the plasma concentration of drug over time
6
Q
what is PHARMACOKINETICS?
A
the study of drug disposition ie. “What the body does to a drug”.
