L06: B-cell Development

Question 1

Pro-B cell

Answer 1

Location- Bone marrow

Surface receptor molecule- Iga/Igb coreceptor

Other surface signalling molecules- C-kit, CD45R

Activity- rearranging heavy chain gene

Question 2

Pre-B cell

Answer 2

Location- Bone marrow

Surface receptor molecule- heavy chain (u) plus surrogate light chain and coreceptor

Other surface signalling molecules- CD25, (alpha chain of IL-2 receptor)

Activity- rearranging light chain gene

Question 3

Immature B cell

Answer 3

Location- bone marrow

Surface receptor molecule- mIgM and coreceptor

Other surface signalling molecules- NO CD25

Activity-