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Pharm Test 4 > L 31 Chemotherapeutics > Flashcards

L 31 Chemotherapeutics Flashcards

1
Q

Antimetabolites MOA?

A

interfere with DNA synthesis

S phase specific

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2
Q

Antimetabolites effective for?

A

rapidly proliferating tumors

leukemia, lymphomas

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3
Q

What do Antimetabolites cause?

A

myelosuppression

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4
Q

What drug is an Antimetabolite?

A

Methotrexate

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5
Q

Admin Methotrexate with?

A

Leucovorin

-> protect from cytotoxicity

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6
Q

What are the Microtubule Inhibitors?

A

Vina Alkaloids
-> Vincristine, Vinblastine

Taxanes
-> Paclitaxel, Docetaxel

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7
Q

Vincristine Tx?

A

pediatric leukemias, solid tumor, adult lymphomas

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8
Q

Vinblastine Tx?

A

testicular cancer, lymphomas

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9
Q

Microtubule Inhibitors have acquired resistance due to?

A

MDR-1 Gene

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10
Q

What drug is Topoisomerase Inhibitors?

A

Etoposide

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11
Q

What is Topoisomerase required for?

A

mitosis

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12
Q

Antibiotics MOA?

A

intercalate into DNA = prevent transcriptions

= DNA strand breaks
Cell cycle non specific

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13
Q

What are the DNA Intercalating/Damaging drugs?

A

Bleomycin

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14
Q

Alkylating Agents MOA?

A

cross link DNA

= prevent gene expression
= apoptosis

cell cycle specific

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15
Q

What can Alkylating Agents induce?

A

leukemia

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16
Q

What drugs are Alkylating Agents?

A

Nitrogen Mustards

Platinum Compounds

Nitrosoureas

Alkyl Sulfonates

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17
Q

What drug is a Nitrogen Mustard?

A

Cyclophosphamide

18
Q

Cyclophosphamide Tx?

A

Burkitt’s Lymphoma

19
Q

Cyclophosphamide SE?

A

potent immunosuppression

20
Q

What drugs are Platinum Compounds?

A

Cisplatin

Carboplatin

21
Q

Cisplatin combo? Tx?

A

w/ bleomycin, etoposide, vinblastine

Testicular Cancer

22
Q

Carboplatin combo? Tx?

A

w/ paclitaxel, cyclophosphamide

Ovarian Cancer

23
Q

Rationally Designed Chemotherapeutics MOA?

A

targeted to the causative molecular abnormality

24
Q

What drug is a Rationally Designed?

A

Imatinib

25
Q

Imatinib MOA?

A

(-) bar-abl tyrosine kinase causative

only in chronic myelocytic leukemia

26
Q

How can tumor cell growth/ survival be inhibited?

A

lowering hormone levels

antagonizing hormone function

27
Q

What is 1st choice for hormonal therapy of estrogen receptor breast cancer?

A

Tamoxifen

28
Q

Tamoxifen & Raloxifene Tx?

A

breast cancer prevention for high risk pt

29
Q

Anti-estrogen drugs?

A

Tamoxifen

Raloxifene

30
Q

Anti-Estrogen MOA?

A

(-) binding of estradiol to the ER and gene transcription

31
Q

Anti-Estrogens are less effective in?

A

premenopausal
bc high estrogen

ER-negative tumors

32
Q

Anti-Androgen Tx?

A

prostate cancer

33
Q

What are Anti-Androgen drugs?

A

Cyproterone – Steroidal

bicalutamide – Non

34
Q

Steroidal Anti-Androgen MOA?

A

(-) androgen binding to the AR

35
Q

Non Steroidal Anti-Androgen MOA?

A

(-) nuclear translocation of AR

36
Q

Anti-Androgens inhibit?

A

AR Dependent gene transcription

37
Q

What are the Immunotherapy drugs?

A

Rituximab

Trastuzumab

38
Q

Rituximab MOA?

A

binds CD20 on non Hodgkins

39
Q

Trasruzmab MOA?

A

antibody to human epidermal growth factor receptor 2

40
Q

Trastuzumab Tx?

A

breast cancers over expressing HER2

41
Q

Rituximab SE?

A

tumor lysis syndrome

Pharm Test 4 (8 decks)

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