L 26, 27 Antidepressants Flashcards by Mac Mac | Brainscape

Q

What are the 5 classes of Antidepressants?

A

Tricyclics

SSRI

SNRI

Atypical or Misc

MAOI

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Q

Tertiary Tricyclics MOA?

A

inactivate “amine” pump on PREsynaptic

(-) NE, SE reuptake

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Q

What drugs are Tertiary Amine Tricyclics?

A

amitryptyline

clomipramine

doxepin

impiramine

trimipramine

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Q

What drugs can be given I.M?

A

amitryptyline

imipramine

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Q

Clomipramine therapeutic use?

A

OCD

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Q

Clomipramine SE?

A

seizure

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Q

Doxepin therapeutic use? SE?

A

increased sedation

no cardio SE

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Q

Trimipriamine therapeutic use?

A

very sedating

moderately anticholinergic

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Q

What drugs are secondary Amine Tricyclics?

A

amoxapine

desipramine

maprotilline

nortyptyline

protryptyline

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Q

Amoxapine MOA?

A

dopaminergic & adrenergic

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Q

Nortryptyline indications?

A

elderly

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Q

What drugs are 1st choice for Monopolar depression?

A

SSRI

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Q

What drugs are SSRI?

A

citalopram
escitalopram

fluoxetine
fluvoxamine

paroxetine
sertaline

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Q

What drugs are SNRI?

A

duloxetine
milnacipran

venlafaxine
desvenalfaxine

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Q

SNRI MOA?

A

(-) SE & NE reuptake

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Q

What drugs Tx fibromyalgia?

A

duloxetine

milnacipran

Q

What drugs are atypical?

A

bupropion
mirtazapine

trazadone
vilazodone

Q

Bupropion MOA?

A

(-) DA, NE reuptake

Q

Trazadone indications?

A

psych pt sleep at night in hospital

Q

MAOI indications?

A

tx resistant depression

refractory depression

Q

MAOI MOA?

A

inactivate enzyme that metabolizes NE & SE

Q

What drugs are MAOI?

A

isocarboxazid

phenelzine

tranylcpromine

Q

What is the Tx for Bipolar Disorder?

A

mood stabilizers

Q

What are Anti depressants drug interactions?

A

CNS Depressants
MAO(-)

Amphetamine
Tryamine
Anesthetic w/ EPI

Pseudoephedrine

Q

Lithium MOA?

A

(-) nerve metabolism
(-) Inositol monophosphatase

alters reputake of SE, NE, DA
Dec. Ptn Kinases

Q

Lithium SE?

A

compliance

GI– Nausea, Diarrhea

Drowsy
Polyuria

Dry mouth, thirsty
Nephrogenic Diabetes

Wt. Gain
Insomnia
Thyroid Enlargement

Q

What drugs Inc excretion of Lithium?

A

osmotic diuretics

acetazolamide

Q

What drugs Dec Lithium excretion?

A

thiazides & loop diuretics

Q

What happens if Lithium is combined with NSAIDs such as indomethacin, naproxen, ibuprofen?

A

dec clearance
Inc reabsorption

-> toxicity

Q

Lamotrigine therapeutic use?

A

long term prophylactic tx bipolar w/out acute mania

Q

Valproic Acid therapeutic use?

A

mania

Q

Carbamazepine therapeutic use?

A

tx resistance bipolar

Q

What drugs are used for maintenance therapy?

A

olanzapine
aripiprazole

risperidone
quetiapine
lurasidone

Q

Secondary Amine Tricyclics MOA?

A

(-) NE reuptake

Q

SSRI MOA?

A

(-) SE reuptake