L 30 NSAIDs Flashcards by Mac Mac | Brainscape

Q

What happens in the Transient phase?

A

vasodilation

Inc capillary perm.

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Q

What happens in the Subacute phase?

A

infiltration of leukocytes, phagocytic cells

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Q

What happens in the Chronic Proliferative phase?

A

tissue degeneration & fibrosis

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Q

What are the Arachidonic acid metabolites?

A

Pos, TXA2, HETE, LT

mediated by COX

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Q

What does COX-1 do?

A

produce prostaglandins

= mediate homeostatic function

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Q

What does COX-2 do?

A

produce prostaglandins

= mediate infl., pain, fever

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Q

NSAIDs therapeutics?

A

no phys. dependence
no resp. depression

Dec. Body temp.

tx. MS disorders

prevent colon cancer, CV disease

niacin tolerability

systemic mastocytosis

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Q

What are the different types of NSAIDs?

A

Salicylates

Propionic Acid Derivatives
Enolic Acids
Arylacetic Acid Derivatives

Sel. COX-2 (-)

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Q

Salicylates MOA?

A

(-) COX1, COX2 irreversibly

(-) Platelet function

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Q

What drugs are Salicylates?

A

Aspirin

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Q

What is Salicylism?

A

mild intoxication from repeated high doses

headache
dizzy
tinnitus
mental confusion

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Q

Salicylates SE?

A

hyperventilate
hyperthermia

altered acid base & electrolyte
impaired platelet

edema, renal failure
convulsion, coma

reye’s

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Q

Salicylates contraindications?

A

child w/ high fever & virus

= Reye’s

use: acetaminophen

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Q

What are Propionic Acid Derivatives?

A

Ibuprofen

Naproxen

Ketoprofen

Oxaprozin

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Q

Ibuprofen Tx?

A

RA

Osteoarthritis

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Q

Ibuprofen SE?

A

GI - Pain, Nausea, Heartburn

Blurred vision
Skin rashes

Q

Oxaprozin administration?

A

1x / day

Q

What drugs are Arylacetic Acid Derivatives?

A

Idomethacin

Ketorolac

Nabumetone

Sulindac

Q

Idomethacin Tx?

A

RA

other arthritis

Q

Idomethacin SE?

A

toxicity limits its use

GI effects
CNS effects

Q

Ketorolac MOA?

A

potent analgesic

moderate anti infl.

Q

Ketorolac administration?

A

Inc. analgesic effect when I.M.

used in ER

Q

Nabumetone SE?

A

low GI effects

Q

What drugs are Enolic Acids?

A

Piroxicam

Meloxicam

Q

Piroxicam advantage?

A

long 1/2 life

Q

What drug can be better tolerated than Aspirin or Idomethacin?

A

Piroxicam

Q

Piroxicam MOA?

A

(-) Neutrophils migration

Q

Piroxicam SE?

A

Edema
Anorexia, Ab. Pain, C/D

Anemia

Dizzy/ Headache

Rash
Tinnitus

Abnorm. Renal Function

Q

Meloxicam MOA? Potency?

A

more sel. COX2 (-) than any other NSAID

less potent than Piroxicam

Q

What are Specific COX-2 (-)?

A

Celecoxib
Refecoxib
Valdecoxib

Q

What is the antidote for APAP OD?

A

N-acetyl-cysteine

Q

Sulindac effects?

A

limit the toxicity of Indomethacin