Krafts- CLL

Question 1

Chronic lymphoproliferative disease is the malignant proliferation of ____________. In the blood and bone marrow. It occurs ONLY in _______ and has a ___________course that is __________.

Answer 1

Lymphocytes
adults
LONG
incurable

Question 2

What is seen in the blood of someone w/ CLL?

Answer 2

Small mature lymphocytes that are boring and all look the same.

Question 3

What are the common characteristics of CLL?

Answer 3

small mature lymphocytes increase in the bone marrow (pt > 40)>
Asymptomatic>
organ infilatration>
hypogammaglobulinemia>
Infection (fatal)

Question 4

What are the immunophenotypic characteristics of CLL?

Answer 4

Positive for : CD20, CD5

Neg: TdT

Question 5

What is the mean survival for CLL?

Answer 5

9 yrs

Question 6

What does hairy cell leukemia look like in the blood and bone marrow?

Answer 6

Blood- hairy cells

Bone marrow- chicken mesh

Question 7

What is an side effect of fibrotic marrow in HCL?

Answer 7

Makes it difficult for RBC to migrate thorugh–> pancytopenia

Question 8

HCL usually presents in/as…..

Answer 8

> 40
M
splenomegaly w/ out lymphadenopathy

Question 9

Hairy cells can be selectively stained w/…

Answer 9

TRAP

Question 10

The immunophenytype of hairy cell is….

Answer 10

Pos: B cell ag (CD25, CD11c)
Neg: CD5

Question 11

What is the prognosis for HCL?

Answer 11

10 yrs

Question 12

What are the charcteristics of prolymphocytic leukemia?

Answer 12

Increased prolymphocytes>
splenogmegaly w/ NO lymphadenopathy>
Increased WBC, decreased Hb and platelets

Question 13

Prolymphocytic leukemia is….

Answer 13

aggressive and rare

Question 14

Blood of people w/ prolymphocytic leukemia has….

Answer 14

ceels w/ dark chromatin and nucleoli

Question 15

What are the characteristics of large granulated lylmphocytic leukemia?

Answer 15

T cells w/ granules
Neutropenia–> freq infections
Long survival