Kebbekus- Lymphoma Cases Flashcards
Describe the staging levels of lymphoma.
1- single LN/organ
2->2 LN on same side of diaphragm
3->2 LN above and below diaphragm
4- widespread disease, multiple organs w/ or without LN involvement
What are lymph tissues?
Waldeyers ring (tonsils and adenoids) Spleen
What is the treatment for localized (I/II) stage hodgkins?
ABVD x 2
Field radiation
What is the treatment for III/IV disease?
ABVD x2
ABVD x2
Intense chemotherapy BEACOPP
Autologous transplant
What are the possible late effects of therapy?
Second malignancy
Heart disease
Lung disease
Impaired fertility
What second malignancies would you be worried about after therapy for HD?
Solid tumors–lung cancer* and breat cancer
Secondary leukemia
Heart disease is an effect of tx for HD because….
it’s associated w/ radtation to mediastinum
What effect of therapy is associated w/ bleomycin containing regimens that are combined w/ chest radiation?
Lung disease
What immunochemistry is associated w/ DLBCL?
Diffuse large b cell lymphoma
CD5-, CD19, CD20, CD23
DLBCL is most common in ….
adults
Prototype for an AGGRESSIVE lymphoma
DLBCL is often treated w/
CHOP cyclophosphamide oncovin= vincristine prednisone doxorubicin
What do we add to CHOP now that has made a big difference?
Rituximab
How long is CHOP given?
18 weeks
What is the most common INDOLENT NHL?
Follicular lymphoma
What percent of Follicular lymphoma cases are at an advanced stage at presentation?
80%
Often asymptomatic