Kebbekus- Lymphoma Cases Flashcards

1
Q

Describe the staging levels of lymphoma.

A

1- single LN/organ
2->2 LN on same side of diaphragm
3->2 LN above and below diaphragm
4- widespread disease, multiple organs w/ or without LN involvement

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2
Q

What are lymph tissues?

A
Waldeyers ring (tonsils and adenoids)
Spleen
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3
Q

What is the treatment for localized (I/II) stage hodgkins?

A

ABVD x 2

Field radiation

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4
Q

What is the treatment for III/IV disease?

A

ABVD x2
ABVD x2
Intense chemotherapy BEACOPP
Autologous transplant

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5
Q

What are the possible late effects of therapy?

A

Second malignancy
Heart disease
Lung disease
Impaired fertility

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6
Q

What second malignancies would you be worried about after therapy for HD?

A

Solid tumors–lung cancer* and breat cancer

Secondary leukemia

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7
Q

Heart disease is an effect of tx for HD because….

A

it’s associated w/ radtation to mediastinum

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8
Q

What effect of therapy is associated w/ bleomycin containing regimens that are combined w/ chest radiation?

A

Lung disease

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9
Q

What immunochemistry is associated w/ DLBCL?

A

Diffuse large b cell lymphoma

CD5-, CD19, CD20, CD23

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10
Q

DLBCL is most common in ….

A

adults

Prototype for an AGGRESSIVE lymphoma

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11
Q

DLBCL is often treated w/

A
CHOP
cyclophosphamide
oncovin= vincristine
prednisone
doxorubicin
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12
Q

What do we add to CHOP now that has made a big difference?

A

Rituximab

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13
Q

How long is CHOP given?

A

18 weeks

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14
Q

What is the most common INDOLENT NHL?

A

Follicular lymphoma

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15
Q

What percent of Follicular lymphoma cases are at an advanced stage at presentation?

A

80%

Often asymptomatic

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16
Q

What traaslocation is associated w/ follicular lymphoma?

A

t(14;18) (q32,a21)

*BCL-2 is translocated to chromosome 14, comes under control of IgH enhancer which leads to overexpression of Bcl-2

BCL-2 chromosome 18q21 inhibits apoptosis

IgH chromosome 14q32

17
Q

What CD marker is associated w/ follicular lymphoma?

A

CD20

18
Q

What is the cure rate for follicular lymphoma? Survival?

A

0%

survival 10-12 years

19
Q

What are the indolent B cell lymphomas?

A
Follicular- most common
CLL/SLL
Marginal Zone
MALT
LPL or waldenstorm
20
Q

What are aggressive BCLs?

A

DLBCL

Mantle cell** could also be put in indolent column

21
Q

What is a HIGHLY aggressive BCL?

A

Burkitt

Younger pt
Start chemo right away
associated w/ EBV

22
Q

What translocation is associated w/ mantle cell lymphoma? Associated w/ what cyclin?

A

t(11,14)
positive for cyclin D1
atypical lymphocytes

Heavy chain on 14 and cyclin D1 translocation

23
Q

Mantle cell lymphoma is positive for what CD?

A

CD20

CD5

24
Q

How do you treat pts w/ advanced mantle cell?

A

Induced w/ RCHOP

autologous stem cell transplant

25
Q

What would flow cytometry show for CLL?

A

Kappa or lambda light chain but NOT both

CD 5, 19, 20, 23

26
Q

Who should be treated for CLL?

A
For advanced disease if:
BM failure
massive splenogmegaly
massive lymphadenopathy
progressive lymphocytosis over 2 motnhs
AIHA and thromobocytopenia
B symtpoms
27
Q

What CDs are characteristic of MALT lymhoma?

A

CDD20

28
Q

MALT is frequently associated w/ what bacteria?

A

H. pylori

29
Q

How do you treat MALT?

A

2-3 rounds of earadication, if no clearing 203 courses XRT and chemo

30
Q

Post transplant lymphoproliferative disorder is associated w/ what drugs?

A

Calcineurin inhbitors

Tacrolimus
Cyclosporine

31
Q

What does EBV induced polyclonal expansionof B cells occur?

A

Suppresson of T cells leads to loss of suppression of B cell prolif.