Fitz- Drug properties you need to know II

Question 1

What are the three types of immunosuppressives?

Answer 1

Glucocorticoids
Antibiotics
Antibodies

Question 2

What are immune system stimulants?

Answer 2

cytokines

Question 3

Dexamethasone and prednisone are?

Answer 3

Glucocorticoids

Question 4

Cyclosporine and tacrolimus are?

Answer 4

Antibiotics

Question 5

Alentuzumab
Denileukin
Gemtuzumab
Ibritumomab
Rituximab
Tositumomab 

are?

Answer 5

Antibodies

Question 6

What are the three cytokines that are immune system stimulants?

Answer 6

IL-2
IFN-alpha
TNF- alpha

Question 7

Drugs that block bcr-abl and block HER2 are drugs that target…..

Answer 7

mutated or over expressed proteins

Question 8

What drugs block bcr-abl?

Answer 8

Dasatinib
imatinib
nilotinib

Question 9

What drugs block Her2?

Answer 9

Lapatanib

Trastuzumab

Question 10

Drugs that block EGFR block….

Answer 10

GFs or GF receptors

Question 11

What are drugs that block EGFR?

Answer 11

Cetuximab
Panitumumab
Erlotinib
Gefitinib
Lapatanib

Question 12

What drug decreases FGF production?

Answer 12

IFN alpha

Question 13

What drug depletes asparagine?

Answer 13

L-asparaginase

Question 14

What drug inhibits proteasome 26?

Answer 14

Bortezomib

Question 15

What drug inhibits HDAC?

Answer 15

Vorinostat

Question 16

What are the three things you can do to block angiogenesis?

Answer 16

Block VEGF
Block mTOR
misc…..

Question 17

What drugs block VEGF?

Answer 17

Bevacizumab

Question 18

What drug blocks mTOR

Answer 18

Everolimus/Temsirolimus
Pazopanib
sorafenib
sunitinib

Question 19

What are the misc drugs taht prevent angiogenesis?

Answer 19

IL-12
IFN-alpha
Thalidomide

Question 20

What are the three drugs that induce differentiation?

Answer 20

Tretinoin (retinoid)
Bearotene (rexionind)
Arsenic trioxide (MISC)

Question 21

What are the EGF drugs that stimulate RBC production?

Answer 21

Darbepoitin
Erythropoietin
Pegepoietin

Question 22

What are the MGFs that stimulate neutrophils and stuff?

Answer 22

Filgastrim
Pegfilgrastim
Sagramostim

Question 23

What does L-asparaginase do?

Answer 23

Turns asparagine to aspartic acid and ammonia. Treating w/ L-asparaginase keeps the cancer cell from getting enough asparagine.

Question 24

What drugs inhibit bcl-abl?

Answer 24

Dasatinib
imatinib
nilotinib

Blocks the activation of TFs via the cascade pathway

Question 25

What drugs target CD20?

Answer 25

Ibritumomab Rituximab Tositumab B lymphocytes

Question 26

What drug targets CD 33?

Answer 26

Gemtuzumab

Question 27

What drug targets CD52?

Answer 27

Alemtuzumab

Question 28

Cylophilin is a protein that allows for calcineurin activation--> decreased secretion of IL-2. What drug blocks clyclophilin?

Answer 28

Cyclosporine

Question 29

What drugs block EGFR?

Answer 29

CEtuximab, panitumumab erlotinib gefitinib lapatanib

Question 30

What drug decreases production of FGF?

Answer 30

IFN alpha

Question 31

Tacrolimus blocks what protein?

Answer 31

FK binding protein Allows for calcineurin activation--> decreased secretion of IL-2

Question 32

What drug blocks HER2 hte transmembrane protein overexpressed in breast cancers?

Answer 32

Lapatinib | Trastuzumab

Question 33

What drug inhibits HDAC?

Answer 33

Vorinostat Keeps chroatin from being trxn silenced

Question 34

What drug prevents a cytokine from inducing and expanding a T cell response?

Answer 34

IL-2

Question 35

What drugs inhibit mTOR?

Answer 35

Everolimus, Terisirolimus Paopanib sorafenib sunitinib

Question 36

What drug inhibits the 26 S proteasome?

Answer 36

Bortezomib

Question 37

What drug inhibits VEGF?

Answer 37

Bevaciximab