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IHO Week 4 > Fitz- Drug properties you need to know II > Flashcards

Fitz- Drug properties you need to know II Flashcards

1
Q

What are the three types of immunosuppressives?

A

Glucocorticoids
Antibiotics
Antibodies

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2
Q

What are immune system stimulants?

A

cytokines

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3
Q

Dexamethasone and prednisone are?

A

Glucocorticoids

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4
Q

Cyclosporine and tacrolimus are?

A

Antibiotics

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5
Q 
Alentuzumab
Denileukin
Gemtuzumab
Ibritumomab
Rituximab
Tositumomab

are?

A

Antibodies

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6
Q

What are the three cytokines that are immune system stimulants?

A

IL-2
IFN-alpha
TNF- alpha

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7
Q

Drugs that block bcr-abl and block HER2 are drugs that target…..

A

mutated or over expressed proteins

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8
Q

What drugs block bcr-abl?

A

Dasatinib
imatinib
nilotinib

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9
Q

What drugs block Her2?

A

Lapatanib

Trastuzumab

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10
Q

Drugs that block EGFR block….

A

GFs or GF receptors

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11
Q

What are drugs that block EGFR?

A 
Cetuximab
Panitumumab
Erlotinib
Gefitinib
Lapatanib
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12
Q

What drug decreases FGF production?

A

IFN alpha

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13
Q

What drug depletes asparagine?

A

L-asparaginase

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14
Q

What drug inhibits proteasome 26?

A

Bortezomib

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15
Q

What drug inhibits HDAC?

A

Vorinostat

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16
Q

What are the three things you can do to block angiogenesis?

A

Block VEGF
Block mTOR
misc…..

17
Q

What drugs block VEGF?

A

Bevacizumab

18
Q

What drug blocks mTOR

A

Everolimus/Temsirolimus
Pazopanib
sorafenib
sunitinib

19
Q

What are the misc drugs taht prevent angiogenesis?

A

IL-12
IFN-alpha
Thalidomide

20
Q

What are the three drugs that induce differentiation?

A

Tretinoin (retinoid)
Bearotene (rexionind)
Arsenic trioxide (MISC)

21
Q

What are the EGF drugs that stimulate RBC production?

A

Darbepoitin
Erythropoietin
Pegepoietin

22
Q

What are the MGFs that stimulate neutrophils and stuff?

A

Filgastrim
Pegfilgrastim
Sagramostim

23
Q

What does L-asparaginase do?

A

Turns asparagine to aspartic acid and ammonia. Treating w/ L-asparaginase keeps the cancer cell from getting enough asparagine.

24
Q

What drugs inhibit bcl-abl?

A

Dasatinib
imatinib
nilotinib

Blocks the activation of TFs via the cascade pathway

25
Q

What drugs target CD20?

A

Ibritumomab
Rituximab
Tositumab

B lymphocytes

26
Q

What drug targets CD 33?

A

Gemtuzumab

27
Q

What drug targets CD52?

A

Alemtuzumab

28
Q

Cylophilin is a protein that allows for calcineurin activation–> decreased secretion of IL-2.

What drug blocks clyclophilin?

A

Cyclosporine

29
Q

What drugs block EGFR?

A

CEtuximab, panitumumab
erlotinib
gefitinib
lapatanib

30
Q

What drug decreases production of FGF?

A

IFN alpha

31
Q

Tacrolimus blocks what protein?

A

FK binding protein

Allows for calcineurin activation–> decreased secretion of IL-2

32
Q

What drug blocks HER2 hte transmembrane protein overexpressed in breast cancers?

A

Lapatinib

Trastuzumab

33
Q

What drug inhibits HDAC?

A

Vorinostat

Keeps chroatin from being trxn silenced

34
Q

What drug prevents a cytokine from inducing and expanding a T cell response?

A

IL-2

35
Q

What drugs inhibit mTOR?

A

Everolimus, Terisirolimus
Paopanib
sorafenib
sunitinib

36
Q

What drug inhibits the 26 S proteasome?

A

Bortezomib

37
Q

What drug inhibits VEGF?

A

Bevaciximab

IHO Week 4 (15 decks)

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