kinetics formulae Flashcards
1
Q
formula for volume of distribution
A
Vd=x/Co (x:dose; Co:where beta phase meets the y-axis, concentration)
2
Q
1st order elimination slope
A
slope=-(ke/2.3)
3
Q
elimination rate constant
A
ke=1/time
4
Q
half life
A
t1/2=.693/ke
t1/2=.693(Vd/Cl)
5
Q
whole body clearance
A
ke=Cl/Vd
6
Q
Drug Imput
A
Ki=Ke(Xmax)
Xmax=1.44KiT1/2
7
Q
Steady State Concentration
A
Css=Ki/Cl
8
Q
Maintenence dose
A
=dosing rate that achieves desired level/f (f: fractional bioavailability)
Used for calculating ORAL doses
9
Q
loading dose
A
a single dose that achieves desired steady state concentration
loading dose=Css x Vd/ f
