Kids Brain Tumors Flashcards

1
Q

Most common pediatric solid tumor

A

brain tumor

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2
Q

Brain tumor peaks

A

Early childhood and late adulthood

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3
Q

INFRATENTORIAL tumors are most common in kids whereas SUPRATENTORIAL tumors are more common in adults

A

ok….

In the first year of life supratentorial tumors are more common

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4
Q

High grade gliomas are …. in peds

A

Rare

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5
Q

Most common childhod tumor

A

Astrocytoma (pilocytic)

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6
Q

Astrocytoma often found where

A

posterior fosterior

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7
Q

Unlike adults and older children, younger children have a relatively high occurence of tumors where

A

cerebellum and brain stem

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8
Q

Neurofibromatosis 1 casues what tumor types

A

Optic Gliomas
Meningiomas
Ependymomas

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9
Q

Neurofibromatosis II causes

A

Bilateral vestibular schwanomas

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10
Q

Tuberous Sclerosis

A

Subependymal giant cell tumors

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11
Q

Von Hippel Lindau

A

Hemangioblastomas

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12
Q

Li Fraumeni syndrome

A

Multiple brain tumor types but commonly astrocytoma and medulloblastoma

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13
Q

clinical manifestations of a supratentorial tumor

A

localizing findings
seizures
hemiparesis

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14
Q

Midline tumor findings

A

Endocrinopathies (diabetes insipidus, growth disorders, decreased vision, visual field issues)

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15
Q

Infratentorial tumors

A

signs of increased ICP due to compression of the fourth ventricle

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16
Q

Brainstem tumors show

A

cranial nerve defect

17
Q

Hydrocephalus

A

associated with 80% of midline brain tumors due to obstruction of ventricular system

  • initial symptoms are early morning intermittent headaches and nausea/vomitting
  • most resolve after mass resection but 15% require shunt or ventriculostomy
18
Q

Intracranial Pressure triad

A

AM headaches, Nausea and vomitting, Lethargy

Other signs are bulging fontanelle, sundowning eyes

19
Q

Most common childhood tumor

A

Low Grade (Pilocytic) Astrocytoma

Low grades are grade I and II and are typically benign
grade III is anaplastic and
grade IV is GBM

20
Q

Low Grade Astrocytoma survival rate

A
  • Good if total resection is achieved
21
Q

EOSINOPHILIC ROSENTHAL FIBERS

A

Juvenile Pilocytic astrocytoma

22
Q

Second most common type of peds tumor

A

medulloblastoma: arises in primitive nerve cells
- If formed in cerebrum it is a primitive neuroectodermal tumor
- Cerebellar : medulloblastoma

23
Q

Peak age of medulloblastoma

A

3-4 yrs

24
Q

Medulloblastoma is generally highly malignant, can compress the 4th ventricle

A

ok

25
Q

Homer Wright Rosettes?

A

Small blue cells seen in a circular patter surrounding a fibrilliar area…..Medulloblastoma

26
Q

Brainstem glioma prognosis

A

Prety much all fatal. surgery contraindicated, Just perform supportive care

27
Q

Diffuse intrinsic pontine glioma

A
  • dismal prognosis
  • median age is 7
  • Corticospinal weakness and CN 6,7,8 deficits

Tumor will engulf the basilar artery on MRI

28
Q

Ependymoma

A

Arise from edendymal linings of ventricles….commonly 4th ventricle

29
Q

Perivascular psuedorossetes?

A

Edendymomas

30
Q

Try to avoid radiating the brain until what age

A

3yrs…axonal growth and synaptogenesis heavy in first three years

Rate of growth and dvelopment slows after age 6 so delaying until age 7 is even better

31
Q

Radiation effects

A

intellectual impairment, memory, cognitive