Anticonvulsants

Question 1

What is a seizure?

Answer 1

High frequency bursts of APs (Influx of calcium and the activation of sodium channels…or the downregulation of inhibitory neurons)q

Question 2

What are the 3 MOAs of anticonvulsant drugs?

Answer 2

• Block the voltage gated Na channel
• Block the voltage gated Ca channel
• Potentiate GABA action

Question 3

Blocking of the voltage gated Na channel does what?

Answer 3

Reduces the ability of the neurons to fire

Question 4

Common Adverse Effects of Anticonvulsants?

Answer 4

suicidal ideation 1-24 weeks after starting the drug

Question 5

GABA potentiators

Answer 5

Clonazepem (benzodiazepine)
Phenobarbital (barbituate)
Felbamate

CPF

Question 6

DOC for status epilepticus?

Answer 6

IV Lorazepem

Question 7

Calcium channel blockers

Answer 7

• Ethosuxamide
• Pregabalin
• Gabapentin

Question 8

Phenytoin MOA

Answer 8

Na channel blocker,,,,remember that these drugs can only inhibitactive or inactive channels. NOT deactive

Question 9

Carbamezapine BBW

Answer 9

agranulocytosis

Question 10

Greatest risk of adverse outcomes in pregnancy>

Answer 10

Valproate

Question 11

Two drugs that potentially cause fetal hydantoin syndrome?

Answer 11

Phenobarbital and carbamezabine

Question 12

Hirsutism?

Answer 12

Phenytoin

Question 13

High risk for SJS of TEN

Answer 13

asians with HLA-B1502

Question 14

What are the two drugs that don’t produce SJS or TEN ever

Answer 14

Clonazepem and lacosamide