Key enzymes in lipid metabolism Flashcards
Location of acetyl CoA carboxylase
In the liver ONLY
Activator of acetyl CoA carboxylase
Citrate
Inhibitor of acetyl CoA carboxylase
Long chain fatty acyl-CoA and AMP
Hormonal activator of acetyl CoA carboxylase
Insulin
Hormonal inactivator of acetyl CoA carboxylase
Glucagon and epinephrine
Induces enzyme synthesis of acetyl CoA carboxylase
Fat-free diet; high carb diet
Represses enzyme synthesis of acetyl CoA carboxylase
High fat diet, fasting, glucagon and epinephrine
What factor is needed in fatty synthesis?
Biotin
What compound does fatty acid synthesis create, and what significance does this play?
Malonyl coA, the only repressor of CPT-1
Location of carnitine palmitoyl transferase-1
Liver
Inhibitor of carnitine palmitoyl transferase-1
Malonyl CoA - always active UNLESS this compound is present
Location of HSTL
Adipose tissue
What does HSTL stand for?
Hormone sensitive triacylglycerol lipase
Hormonal activator of HSTL
Epinephrine and ACTH
Hormonal inactivator of HSTL
PGE and insulin
Reaction catalyzed by HSTL
TAG degradation
Location of HMG-CoA synthase
Liver mitochondria
Reaction catalyzed by HMG-CoA synthase
Acetyl CoA from ketone bodies
Location of acetoacetate:succinyl-CoA transferase
Not the liver
Reaction catalyzed by acetoacetate:succinyl-CoA transferase
Ketone metabolism
Location of HMG-CoA reductase
Liver
Inhibitor of HMG-CoA reductase
Cholesterol, AMP, mevalonate
Hormonal activator of HMG-CoA reductase
Insulin
Hormonal inactivator of HMG-CoA reductase
Glucagon
