Hexose transporters

Question 1

Mechanism of SGLT1

Answer 1

Co-transports one glucose/galactose along with two sodium ions

Question 2

Hexose that is not transported by SGLT1

Answer 2

Fructose

Question 3

Where is SGLT1 expressed?

Answer 3

In the intestinal mucosa and kidney tubules

Question 4

Mechanism of SGTL2

Answer 4

Co-transports glucose and sodium ions.

Question 5

Hexose(s) not transported by SGLT2

Answer 5

Galactose and fructose

Question 6

Where is SGLT2 expressed?

Answer 6

Kidney tubules

Question 7

Mechanism of GLUT1

Answer 7

Insulin-independent plasma membrane transporter

Question 8

Where is GLUT1 expressed?

Answer 8

RBCs, brain, endothelial cells, fetal tissues

Question 9

Mechanism of GLUT2

Answer 9

Insulin independent. Allows glucose to flow in two different directions.
Also serves as a “glucose sensor” in the pancreas

Question 10

Where is GLUT2 expressed?

Answer 10

Mostly in the liver, where there are very high concentrations of glucose. Also present in the intestines, kidneys, and pancreas

Question 11

Mechanism of GLUT3

Answer 11

Insulin-independent transporter

Question 12

Where is GLUT3 expressed?

Answer 12

In the brain

Question 13

Mechanism of GLUT4

Answer 13

Insulin-DEPENDENT transporter that “gets” glucose after a meal; high affinity. Not active during fasting

Question 14

Where is GLUT4 expressed?

Answer 14

Muscle, heart, and adipocytes

Question 15

Mechanism of GLUT5

Answer 15

Fructose transporter

Question 16

Where is GLUT5 expressed?

Answer 16

Skeletal muscle, adipocytes, brain, sperm, and erythrocytes