Key Bacteria Focus 🕵🏻

Question 1

Staph A infections

Answer 1

Endocarditis 
Food poisoning 
MRSA
Skin + wound infection 
Osteomyelitis 
Bacteraemia 
Sepsis

Question 2

Staph A virulence factors

Answer 2

Coagulase
Lipase
Hyaluronidase
Beta lactamase
Superantigens (TSST1, enterotoxin)
Panton Valentine leukocidin 
Protein A anti-opsonisation  in
Staphyloxanthin (antioxidant) 
Biofilm

Question 3

Gram positive recognition.

Answer 3

TLR2 recognises lipoteichoic acid, PtG

Nod2 recognises PtG

Question 4

Staph A treatment

Answer 4

Penicillin

Vancomycin + clindomycin + IVIG for résistant

Question 5

Staph A typing

Answer 5

Gram positive clusters
Catalase positive
Facultative anaerobe

Question 6

C diff typing

Answer 6

Gram positive
Spore forming
Anaerobe

Question 7

C diff infections

Answer 7

Diarrhoea
Abdo pain
Pseudomembranous colitis
Perforations + secondary g-ve leaking

Question 8

C diff virulence factors

Answer 8

Toxin A
Toxin B (major one, inactivates Rho) 
Adhesins
Flagellae
Pili type 4 secretion 
Spores 
Biofilm

Question 9

C diff treatment

Answer 9

Metronidazole

Vancomycin

Question 10

E. coli typing

Answer 10

Gram negative rod

Anaerobe

Question 11

E. coli infections

Answer 11

UTI
Meningitis
Gastroenteritis
Haemolytic uraemic syndrome

Question 12

E. coli virulence factors

Answer 12

Fimbriae
Enterotoxin
Adhesins
Haemolysins
Shiga toxin
Biofilm

Question 13

Gram negative recognition.

Answer 13

TLR4 recognises LPS

Nod1 recognises PtG

Question 14

E. coli treatment

Answer 14

Gentamicin

Question 15

Strep pneumoniae typing

Answer 15

Gram positive coccus

Question 16

Strep pneumoniae infections

Answer 16

Pneumonia

Meningitis

Question 17

Strep pneumoniae virulence factors

Answer 17

Capsule
Pneumolysin 
Pili
Adhesins
Anticomplement
Proteases
Fibronectin-binding proteins

Question 18

Strep pneumoniae treatment

Answer 18

Clindamycin