Kell, Duffy, Kidd And Lutheran Blood Groups Flashcards
Rated as second to D antigen in immunogenicity
Kell antigen (K)
Kell antigen is destroyed orinactivated by
Sulfuhydryl reagents like
AEY
DTT
ZZAP
Most common antibody seen in blood bank
Anti-K
Anti-K chromosome location
7
Lacks Kell antigen and have no membrane abnormality
KO or K null phenotype
Lacks Kx antigen (might precursor for Kell Antigen)
McLeod Phenotype
Rare phenotype that has abormal RBC morphology
McLeod Phenotype
Common among males from Chronic Granulomatous Disease
McLeod Phenotype
Duffy antigens
Fya and Fyb
Most important antigen associated with transfusion medecine in duffy blood group
Fya and Fyb
Well developed at birth and can eaily destroyes by common proteolytic enzyme
Fya and Fyb
Important anthropological marker for African blacks
Fy (a-b-)
Fy (a-b-) were shown to resist infection caused by
Plasmodium vivax and Plasmodium knowlesi
Common antibodies in duffy
Anti-Fya
Kidd antigens
Jka and Jkb
Resist lysis in 2M urea and occurs in Mongoloids
Jk(a-b-)
Reactivity enhanced by enzyme treatment
Jka and Jkb
Common cause of delayed HTR
Anti-Jka and Anti-Jkb
Lutheran genes are located on
Chromosome 19
lutheran genes closely linked with
Secretor locus
Lutheran antige
Lua and Lub
Rare phenotype with decreased Kell system antigen expression and abnormal red cell morphology, which has been associated with X-linked chronic granulomatous disease (CG), which is a rare disorder affecting only the males
McLeod Phenotype
develop a slow, progressive form of muscular dystrophy between ages 40 and 50, which i: associated with areflexia (a lack of deep tendon flexes), choreiform movements (well-coordinated but involuntan
movements), and cardiomegaly leading to cardiomyopathy, they have elevated serum creatine phosphokinase (CPK) levels of the MM type and carbonic anhydrase Ill levels
McLeod Phenotype
Parasities that are associated with Fya and Fyb
Plasmodium vivax
Plasmodium knowlesi
