ABO Flashcards
Type 1 Linkage
Beta 1,3
Type 1 Origin
Plasma
Type 1 Controlling genes
H,A,B,Se and Lewis
Type 2 linkage
Beta 1,4
Type 2 origin
Synthesized on erythrocyte precursor
Type 2 controlling gene
H,A,B
Branched A Antigen
A1
Linear A antigen
A2
500 000 A antigen/adult red cells
A2
Bombay phenotype
hh
Very rare , does not make transferase to form H antigen
hh
RBC fail to react with Anti-A, anti-B, anti H lectin
Bombay phenotype
Rare phenotypee in which the RBC are completely devoid oh H antigens or have small amount of H antigen present
Parabombay
RBC pf thse individuals express weak forms of A and B antigen, which are primarily detected by absorption and elution studies
PARABOMBAY
A secretor subtances
A, H Substances
B secretor substances
B, H substance
AB secretor substances
A,B,H subtances
O secretor substances
H substances
Nonsecretor (sese) substances
None
Fluid in which A, B and H Substances can be detected in secretor
Saliva
Tears
Urine
Digestive juices
Bile
Milk
Amniotic fluid
Pathological fluids: pleural, peritoneal, pericardial, ovarian cyst
Acquired B antigen caused
Proteus vulgaris
Acquired A antigen cause
Proteus Mirabilis
Can also result from increased pemeability of the intestinal wall and subsequent absorption of bacterial polysaccharide ( E.coli 086) on the erythrocyte
Acquired B antigen
Tn-activated erythrocyte
Acquired A antigen
What blood group?
IgM
Reacts at room temp
Naturally Ocurring
Cannot cross the placenta
A
What blood group?
Predominantly IgG
Reacts at 37
Immune antibody
Can cross the placenta
O
Antibody produces by B
Anti- A
Antibody produced by A
Anti-B
Antibodies produced by AB
None
Antibodies produced by O
Anti-A
Anti-B
Anti- AB
