Kartagner's Syndrome

Question 1

Kartagner’s Syndrome Define:

Answer 1

Kartagener’s Syndrome is a rare autosomal recessive genetic ciliary disorder comprising the triad of situs inversus, chronic sinusitis, and bronchiectasis.

Question 2

Kartagner’s Syndrome Pathogenesis:

Answer 2

Dynein arm defect results in immotile cilia.

Question 3

Kartagner’s Syndrome key feature:

Answer 3

Recurrent chest infections and sub-fertility.

Question 4

Kartagner’s Syndrome Features:

Answer 4

Dextrocardia or complete situs inversus
Bronchiectasis
Recurrent sinusitis
Sub-fertility - secondary to diminished sperm motility and defective ciliary action in the fallopian tubes.