JVD 2017 #2 - Comparison of Histological and Proliferation Features of Canine Oral Squamous Cell Carcinoma Based on Intraoral Location: 36 Cases Flashcards
What is PCNA, why is it important?
- PCNA (proliferating cell nuclear antigen) is a 36 kDa protein of DNA polymerase involved in cellular control of replication
- Overexpression related to prognosis and recurrence rate in OSCC in people
What is Ki 67?
- Ki- 67 is a nuclear protein expressed in all cell cycle phases except G0
- Considered a proliferation marker
What was the goal of the study?
to evaluate histological and proliferation difference for tumors based on intraoral location
What proportion of tumors were located in each location?
- 36 total tumors
- 22 gingival (61%)
- 3 tongue (8%)
- 3 buccal mucosa (8%)
- 8 tonsillar (22%)
What was found with respect to PCNA and Ki-67 staining with regard to tumor location?
•Neither Ki-67 nor PCNA PI was associated specifically with any of the intraoral locations evaluated
What association was found between grade and location?
- •Grade of SCC associated with location
- no grade III in tongue or buccal mucosa (also no lymph node mets),
- more grade III in tonsil
What association was found between PCNA Proliferation index and grade?
•PCNA PI showed significant Association with grade; lower PI found in grade I
Which Marker was associated with lymph node metastases?
PCNA Proliferation index