JVD 2017 #2 - Comparison of Histological and Proliferation Features of Canine Oral Squamous Cell Carcinoma Based on Intraoral Location: 36 Cases Flashcards

1
Q

What is PCNA, why is it important?

A
  • PCNA (proliferating cell nuclear antigen) is a 36 kDa protein of DNA polymerase involved in cellular control of replication
  • Overexpression related to prognosis and recurrence rate in OSCC in people
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2
Q

What is Ki 67?

A
  • Ki- 67 is a nuclear protein expressed in all cell cycle phases except G0
  • Considered a proliferation marker
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3
Q

What was the goal of the study?

A

to evaluate histological and proliferation difference for tumors based on intraoral location

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4
Q

What proportion of tumors were located in each location?

A
  • 36 total tumors
  • 22 gingival (61%)
  • 3 tongue (8%)
  • 3 buccal mucosa (8%)
  • 8 tonsillar (22%)
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5
Q

What was found with respect to PCNA and Ki-67 staining with regard to tumor location?

A

•Neither Ki-67 nor PCNA PI was associated specifically with any of the intraoral locations evaluated

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6
Q

What association was found between grade and location?

A
  • •Grade of SCC associated with location
  • no grade III in tongue or buccal mucosa (also no lymph node mets),
  • more grade III in tonsil
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7
Q

What association was found between PCNA Proliferation index and grade?

A

•PCNA PI showed significant Association with grade; lower PI found in grade I

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8
Q

Which Marker was associated with lymph node metastases?

A

PCNA Proliferation index

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9
Q
A
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