JVD 2015 #4 - Evaluation of an Accelerated Chemoradiotherapy Protocol for Oropharyngeal Squamous Cell Carcinoma in 5 Cats and 3 Dogs Flashcards

1
Q

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

which types of SCC have higher metastatic rates?

what have primary treatment options been historically?

what is typically the cause of death in cats?

A

tonsillar and lingual;

surgery and radiotherapy;

euthanasia secondary to local disease (poor quality of life)

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2
Q

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

what is accelerated radiotherapy?

hyper fractionated?

A

accelerated involves total tx delivered over a shorter time period,

multiple small doses delivered at shorter intervals (in this study BID x 9d);

hyperfractionated = larger number of fractions

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3
Q

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

how was radiation delivered?

with what protocol?

what chemotherapy was used and why?

A

linear accelerator;

BID for 7/9 days in a run; 3.5Gy fractions for a total of 49Gy with a minimum of 6h btwn fractions;

carboplatin as a radio sensitizer

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4
Q

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

how many cats received a complete response (complete regression of all measurable dz)? partial response?

what were the side effects?

A

4/5 cats had complete remission; partial 1/5;

grade 2 oral mucositis, grade 2 and 3 cutaneous dermatitis

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5
Q

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

how many cats died secondary to tumor recurrence? due to mets?

A

1 (stage III);

1 with tonsillar SCC had pulmonary mets which developed after treatment

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6
Q

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al, how many dogs achieved complete remission by 6-10weeks following completion of therapy?

A

all 3/3

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7
Q

According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,

how many dogs died secondary to metastatic disease what were the other outcomes?

A

1/3 due to distant mets; 1 to cardiac failure, and 1 still in complete remission

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