JVD 2015 #4 - Evaluation of an Accelerated Chemoradiotherapy Protocol for Oropharyngeal Squamous Cell Carcinoma in 5 Cats and 3 Dogs Flashcards
According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,
which types of SCC have higher metastatic rates?
what have primary treatment options been historically?
what is typically the cause of death in cats?
tonsillar and lingual;
surgery and radiotherapy;
euthanasia secondary to local disease (poor quality of life)
According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,
what is accelerated radiotherapy?
hyper fractionated?
accelerated involves total tx delivered over a shorter time period,
multiple small doses delivered at shorter intervals (in this study BID x 9d);
hyperfractionated = larger number of fractions
According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,
how was radiation delivered?
with what protocol?
what chemotherapy was used and why?
linear accelerator;
BID for 7/9 days in a run; 3.5Gy fractions for a total of 49Gy with a minimum of 6h btwn fractions;
carboplatin as a radio sensitizer
According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,
how many cats received a complete response (complete regression of all measurable dz)? partial response?
what were the side effects?
4/5 cats had complete remission; partial 1/5;
grade 2 oral mucositis, grade 2 and 3 cutaneous dermatitis
According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,
how many cats died secondary to tumor recurrence? due to mets?
1 (stage III);
1 with tonsillar SCC had pulmonary mets which developed after treatment
According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al, how many dogs achieved complete remission by 6-10weeks following completion of therapy?
all 3/3
According to “Evaluation of an accelerated chemoradiotherapy protocol for oropharyngeal SCC in 5 cats and 3 dogs” by Reject, Hren, et al,
how many dogs died secondary to metastatic disease what were the other outcomes?
1/3 due to distant mets; 1 to cardiac failure, and 1 still in complete remission