Joint Diseases (Pathology)

Question 1

ages of RA

Answer 1

any

Question 2

most common age of RA

Answer 2

women 20-50

Question 3

cells involved in RA

Answer 3

CD4 cells aggregating and secreting cytokines to attract b cells and macrophages –> inflammatory response & pannus

Question 4

Antibodies formed in RA

Answer 4

IgM vs Fc of self IgG - measured as Rheumatoid Factor (RF)

Question 5

joints involved in RA characteristically

Answer 5

MCP, PIP, with ulnar deviation

small joints of hands & feet, followed by wrists, elbows, ankles, knees

Question 6

dip joint involvement suggests

Answer 6

osteoarthritis

Question 7

swan-neck abnormality

Answer 7

RA sign

Question 8

appearance of rheumatoid nodule

Answer 8

acellular center (eosinophilic, fibrinoid)
palisaded histiocytes
may be granulation tissue rimmed

Question 9

meaning of pannus

Answer 9

membrane of granulation tissue

Question 10

is there pus in a rheumatoid nodule?

Answer 10

no

Question 11

type of vasculature in rheumatoid nodules

Answer 11

high endothelial, highly permeable to lymphocytes

Question 12

calcium urate crystals in joint

Answer 12

gout

Question 13

location of gout

Answer 13

great toe, distal joints

Question 14

swollen area of urate precipitation

Answer 14

tophus

Question 15

yellow when parallel to polarized light

Answer 15

urate –> gout

Question 16

blue when parallel to polarized light

Answer 16

calcium phosphates –> pseudogout

Question 17

pseudogout usual location

Answer 17

knees

Question 18

predisposing factors for pseudogout

Answer 18

damage from diabetes, iron overload, etc

Question 19

salmonella in a joint

Answer 19

sickle cell with infectious arthritis

Question 20

usual bugs for infectious arthritis

Answer 20

G+ cocci (staph, strep)

G- rods (E. coli, pseudomonas)

Question 21

spread of infection to joints

Answer 21

usually hematogenous, or traumatic

Question 22

gonococcal arthritis involves how many joints?

Answer 22

multiple

Question 23

most infectious arthritis joint number

Answer 23

single

Question 24

mobile mass located on hands or feet

Answer 24

ganglion cyst/synovial cyst/bible bumps

Question 25

well circumscribed tumor, yellow with lipid-laden macrophages, near joints in fingers

Answer 25

giant cell tumor of tendon sheath

Question 26

DDx of giant cell growth

Answer 26

giant cell tumor, TB

Question 27

localized destructive lesion in a single joint with proliferation of synovium, hemosiderin

Answer 27

pigmented villonodular synovitis