Bone Neoplasms (Pathology) Flashcards
Facial bones, 40-50
Osteoma
cortical tibia & fibula M:F 2:1 teens, 20s, pain decreased with aspirin, increased w/EtOH radioleucent core w/rim
osteoid osteoma
leucent, ground-glass w/demarcated borders
whirled histo w/islands of cartilage
fibrous dysplasia
children >2 (very common)
metaphysis of femur & prox tibia
scooped-out appearance
storiform
fibrous cortical defect
Male child/adolescent
Humerus/femur
thin margins, appearing lytic
solitary bone cyst
spongy with blood
long bones & vertebral column
children & young adults
aneurysmal bone cyst
pedonculated cauliflower mass on metaphysis
single & multiple?
osteochondroma aka exostosis
multiple heredetary exostosis
medulary cavity of hands & feet tubular bones
juxtacortical w/scalloped endosteal surface
single or multiple?
chondroma (singular)
Ollier disease & Maffucci syndrome (multiples)
knee epiphysis
20-40 yo
soft, hazy neoplasm
soap-bubble appearance
giant cell tumor
DDx: TB infection -> Potts disease
<20 yo or older knee metaphysis calcified bone in neoplasm codman triangle (lifted periosteum) large pleomorphic cells lung mets painful
osteosarcoma
older mode: Paget’s disease (look for high volume heart failure) or radiation
genetics: Rb & MDM2
35-60 yo axial skeleton (rarely distal) diaphysis or metaphysis radioleucent nodules w/scalloped endosteal surfaces mitotic figures
chondrosarcoma
surgery only (no chemo) can come from osteochondroma (rarely)
small blue-cell tumor
10-15 yo, white
medullary cavity w/onion-skin appearance on XR
homer-wright rosettes
Ewing sarcoma
11:22 translocation
neuroectoderm derived
good prognosis
Mets w/lytic appearance
all but PC
Mets w/osteoblastic appearnce
PC
