JC71 (Surgery) - BPH, Bladder outlet obstruction, Urinary retention Flashcards

1
Q

Physiology of bladder storage

  • How does the bladder accommodate urine at low pressure and retain it?
A

Storage: efficient and low-pressure filling, lower pressure storage and perfect continence
→ Bladder outlet remain closed at rest or despite ↑intra-abd pressure
→ No involuntary bladder contraction (detrusor overactivity)

Receptive relaxation of bladder: ↓tension in response to ↑volume → maintain low intravesical pressure
□ Pathological: bladder pathologies may lead to hypocompliant bladder → ↑↑pressure during filling

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2
Q

Physiology of bladder emptying

How does the bladder expel urine and control emptying rate?

A

Emptying: periodic voluntary urine expulsion at low pressure
→ Coordinated contraction of bladder smooth muscles at adequate magnitude and duration
→ ↓resistance at bladder outlet
- Proximal sphincter mechanism (PSM) at bladder neck by autonomic control
- Distal sphincter mechanism (DSM) by somatic control
→ No anatomical obstruction

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3
Q

Afferent sensory pathway from bladder to brain?

A

Afferent:
→ Stretch receptors detects bladder distension
→ Pathway:
- Aδ for signals for distension
- C-fibres for signals for irritation/pain
- Along hypogastric, pelvic (majority), pudendal nerves
→ Target: higher centres

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4
Q

Brain centers for micturition?

A
  1. Pontine micturition centre (PMC, Barrington’s nucleus) → coordinates between filling/voiding
  2. Suprapontine control by cerebral cortex → conscious inhibition of involuntary voiding
    (not inborn, developed from toilet training)
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5
Q

Efferent pathways from brain to control micturition?

  • Parasympathetic, sympathetic, somatic
A

SN: from T10-L2

  • Pathway: lumbar splanchnic → hypogastric plexus
  • Action: maintain continence by ↓detrusor contraction (β3-adren) + ↑bladder outlet contraction (α1-adren)

PN: from S2-4

  • Pathway: pelvic splanchnic
  • Action: initiate voiding by ↑detrusor contraction (M3-musc)

Somatic: from Onuf’s nucleus

  • Pathway: pudendal n.
  • Action: maintain continence by ↑external sphincter contraction (nAChR)
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6
Q

Neural control of bladder storage phase

  • Afferent
  • Reflex
  • Efferent
  • Effector organs
A

□ Initiation: bladder empty → afferent Aδ sensory fibres send low-level firing signals to higher centres

□ Vesicosympathetic (storage) reflex initiated

□ Effects:
→ +ve SN pathway
→ -ve PN pathway
→ +ve somatic pathway

□ Actions:
→ Detrusor relaxation (β3-adren)
→ Internal urethral sphincter contraction (α1-adren)
→ External urethral sphincter contraction (nAChR)

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7
Q

Neural control of bladder storage phase/ Guarding reflex

  • Afferent
  • Relay pathways
  • Efferent
  • Effector organs
A

□ Initiation: bladder empty → afferent Aδ sensory fibres send low-level firing signals to higher centres

□ Vesicosympathetic (storage) reflex initiated

□ Effects:
→ +ve SN pathway
→ -ve PN pathway
→ +ve somatic pathway

□ Actions:
→ Detrusor relaxation (β3-adren)
→ Internal urethral sphincter contraction (α1-adren)
→ External urethral sphincter contraction (nAChR)

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8
Q

Neural control of bladder emptying/ Voiding reflex

  • Afferent
  • Relay pathways
  • Efferent
  • Effective organ actions
A

□ Initiation: bladder distension → afferent fibres to cortex → Higher center/ Cortical signals to PMC + removal of inhibition from cerebral cortex → PMC initiates voiding reflex

□ Effects:
→ -ve SN pathway
→ +ve PN pathway
→ -ve somatic pathway

□ Actions:
→ Detrusor contraction (M3-musc)
→ Internal urethral sphincter relaxation
→ External urethral sphincter relaxation

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9
Q

List the efferent receptors in Detrusor muscle, Bladder neck/ prostate, and external/ Rhabdosphincter

A

Detrusor:
B3 adrenergic receptor - relaxation
M3 muscarinic receptor - contraction

Bladder neck/ prostate:
a1 adrenergic - contraction

External/ Rhabdosphincter:
- Nicotinic - contraction

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10
Q

Effect of spinal cord injury to micturition control?

A

Detrusor sphincter dyssynergia (DSD):
□ Cause: spinal cord injury, pontine stroke

□ Mechanism: interruption of descending control by pontine micturition centre → i.e. failure of detrusor-sphincter coordination → synchronous contraction of both detrusor and sphincters

□ Consequence: ↑↑urinary tract pressure → upper tract damage

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11
Q

Compare presentation of acute vs chronic urine retention (AROU vs CROU)

which type is a/w neural damage

A

□ Acute retention of urine (AROU): sudden onset, painful
→ Occurs when innervation is normal, eg. BPH

□ Chronic retention of urine (CROU): usually painless with vague lower abdominal distension
→ Occurs when innervation is abnormal, eg. DM

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12
Q

Risk factors of urine retention in male

Common causes of urine retention in male

A

Male: RF
↑age
↑prostate size, ↑BPH symptoms
↓max urine flow rate

Causes: Bladder outlet obstruction most common:

BPH (53%)*****
constipation (7.5%), 
CA prostate (7%), 
urethral stricture (3.5%), 
clot retention (3%), 
bladder/urethral stone (2%),
bladder neck stenosis (post-prostate surgery), 
phimosis, 
CA bladder
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13
Q

Common causes of urinary retention in female

A

Causes:
Detrusor underactivity: Detrusor hypocontractility, drug-induced, bladder overdistention (e.g. post-anesthesia)

Obstructive causes (rarer): organ prolapse (eg. cystocele), gynaecological tumours (eg. fibroid)

Neurogenic bladder: neurological deficit e.g. SCI, CVA, PD

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14
Q

2 major pathological processes that cause AROU

A

Increase resistance to urine flow/ Obstructive:

  • Mechanical: strictures, clots, stones
  • Dynamic: large prostate, bladder neck tone
  • Functional: e.g. neuropathic bladder

Impaired detrusor contraction/ Neurogenic:

  • Drug induced
  • Bladder overdistension (e.g. post-anesthesia)
  • Neuropathic bladder

Combination

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15
Q

Mechanical causes of bladder outlet obstruction

- Mural, intraluminal, extramural

A

Mural:
Urethral stricture from prev instrumentation or STDs
Bladder neck tumours
Urethritis

Intraluminal:
Stones
Clot retention in haematuria
Foreign bodies

Extramural compression:
BPH
CA prostate
Constipation/ stool impaction
Pelvic tumours
Prostatitis, pregnancy, pelvic organ prolapse (cystocele, rectocele, uterovaginal prolapse)
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16
Q

Drug-induced bladder outlet obstruction

ddx drugs

A

Drug-induced:
Sympathomimetics: α-agonists (cold medications), β-agonists (bronchodilators), MDMA

Anticholinergics: anticholinergics (bronchodilators), antipsychotics, antispasmodics (opioids), antihistamines, antidepressants, disopyramide (class Ia antiarrhythmic)

17
Q

Causes of Neurogenic bladder

  • Brain, spinal cord, nerves
A

Brain: stroke, Parkinson’s disease, MS, Normal pressure Hydrocephalus, MSA

Spinal cord: trauma, vertebral metastasis, spinal stenosis, transverse myelitis, spinal cord haematoma/abscess, spinal cord tumour

Nerves: diabetic neuropathy, radical pelvic surgery, Guillain-Barre syndrome

18
Q

Causes of acute overdistension of bladder

A

↑urine production: excessive fluid intake (esp alcohol)

↓voiding: post-anaesthesia (GA, epidural), analgesics, painful peri-anal pathologies, prolonged immobility

19
Q

Common precipitating factors of AROU

A

Constipation

UTI

Immobility

Painful peri-anal conditions: thrombosed hemorrhoids, perianal abscess

Excessive fluid intake (alcohol)

Drugs: Sympathomimetics, anticholinergics, Anesthesia/ analgesia

20
Q

Outline history taking questions for urinary retention

5 main parts

A

Confirm AROU:

  • r/o anuria or oliguria by bladder USG/first catheterized urine vol
  • painful or painless?

Characterize current episode, ask precipitating factors

Find etiology:

  • BOO: obstructive LUTS S/S
  • BPH and complications: Gross haematuria, UTI, Stones, Renal impairment (uremic S/S)
  • Neurological: LL weakness, Sphincter function, Back pain, CVA, PD…etc
  • Drugs
  • Iatrogenic strictures: prostate surgery, TURP…etc
  • STD, Prostatitis

Screen for malignancy:
Constitutional symptoms, gross painless haematuria

Complications
UTI: fever, dysuria, irritative symptoms, haematuria
Stone disease
Renal failure: vomiting, lethargy, drowsiness, uremic rash

21
Q

Detail the surgical and medical history for urinary retention

A

Medications:

BPH medications (eg. α-blockers, 5-α reductase inhibitors)
Anticholinergics, antimuscarinics 

Surgery: iatrogenic stricture
Prostate surgery
Urethral instrumentation

22
Q

Outline P/E for urinary retention

A
  1. Vitals: Septic, Uraemic?
  2. urethral catheter output → any gross haematuria?
  3. Abdominal exam
    - Palpable bladder: tender mass upon deep suprapubic palpation
    - pelvic masses: fibroid, gravid uterus, ovarian cyst
    - Faecal loading
    - Bilateral ballotable kidneys due to hydronephrosis
    - Phimosis
  4. DRE: ± PV exam if female
    □ Signs of cord compression: saddle anaesthesia, anal tone, perianal sensation
    □ Painful peri-anal conditions
    □ Prostate: size, consistency and tenderness (high-rising prostate → C/I to Foley insertion)
    □ Faecal impaction
  5. LL neurological examination:
    □ LMN paralysis
    □ Sensory level
23
Q

Bladder outlet obstruction

  • S/S
  • Complications
A

S/S:

Weak stream, hesitancy and intermittency, terminal dribbling, incomplete emptying, overflow incontinence, lower abdominal distention
Uremic symptoms (obstructive nephropathy)

Complications:

  • Urine retention
  • Recurrent UTI
  • Bladder calculi
  • Hydroureter and hydronephrosis
  • Renal impairment/ acute-renal failure
24
Q

Uroflowmetry can diagnose bladder outlet obstruction

True or false

A

False

Uroflowmetry cannot differentiate Detrusor hypocontraction and BOO

Need Urodynamic studies to dx BOO

25
Q

First-line diagnostic test and treatment of urinary retention

A

Bladder scan: ≥300mL in a patient unable to void suggests urinary retention, ≥1L suggests chronic retention of urine

Immediate bladder decompression by
□ Urethral catheterization (first-line) by 14-18Fr Foley’s catheter
□ Suprapubic catheterization (SPC)

26
Q

Urethral catherization

  • equipment
  • forms for different pathologies
  • C/I
A

Urethral catheterization (first-line) by 14-18Fr Foley’s catheter

Failure to pass into bladder can be due to

  • Enlarged prostate → use thicker (20-22 Fr) catheters
  • Urethral stricture → use thinner (10-12 Fr) catheters

C/I: recent urologic surgery, urethral injury, urethral strictures (high-rising prostate, blood at urethral meatus)

27
Q

Suprapubic catherization (SPC)

  • Indications
  • C/I
  • Complications
A

Indications: failed urethral catheterization, Hx of urethral trauma (eg. straddle injury), long-term bladder drainage expected (>3w)

C/I: non-distended bladder (higher risk of bowel injury), uncorrected bleeding tendency, known/suspected urothelial CA (seeding)

Complications: bowel perforation, rectal injury (overshooting), haematuria

28
Q

Urethral cathertization

Procedure, 4 steps

A
  • Aseptic technique: clean patient’s genital area with hibitane, drape surrounding areas
  • Intraurethral LA: apply xylocaine jelly around meatal opening → milk jelly down urethra → wait 5min
  • Insertion: use forceps to hold 14Fr Foley’s catheter → insert all the way down using no touch technique
  • Fixation: inject 10mL of water into balloon → withdraw catheter until resistance encountered
29
Q

Suprapubic catherization (SPC)

  • Process, 2 steps
A
  • LA injected 2FB above pubic symphysis
  • Small incision made in skin/fascia → insert trocar-type suprapubic tube → catheter advanced over trocar → sutured in place → look for gush of urine
30
Q

First-line investigations for urinary retention

A

Investigations:
□ Blood: CBC (leukocytosis), LFT, RFT (obstructive nephropathy)

□ Catheterized urine: biochemistry, microscopy, C/ST

□ KUB for stones or faecal loading

□ Do NOT take PSA → AROU can cause false elevation (to be done 4-6w later)

31
Q

Urodynamic study for urinary retention

  • Metrics measured
A

Intravesical and rectal pressure

Detrusor pressure

Uroflow rate

Sphincter function EMG

Bladder volume

Cystogram and reflux (video)

> > > high detrusor pressure, low uroflow is diagnostic of BOO

32
Q

List 3 complications after relieving AROU and pathophysiology

A
  1. Post-obstructive diuresis: >200mL/h urine ×≥2h or >3L urine in 24h
    MoA: tubular damage → ↓concentrating ability → rapid fluid and solute loss
  2. Haemorrhage ex-vacuo (transient haematuria):
    MoA: bladder mucosal disruption with sudden emptying of greatly distended bladder
  3. Transient hypotension
    MoA: vagovagal response or relief of pelvic venous congestion
33
Q

Management options for AROU due to BPH

A

Initiate BPH medications

Trial without catheter (TWOC): ≥2 TWOC attempts before considering surgical therapy
→ Involves: removal of catheter after 1-2w → determine whether pt can void spontaneously
- Success (20-40%): perform urodynamic evaluation for confirmation of BOO
- Failure: if cannot void + bladder volume >400mL → recatheterize

Failed TWOC ×2:
→ Long-term catheterization
→ Clean intermittent self-catheterization
→ Elective TURP