Jaundice In Pregnancy

Question 1

ACUTE FATTY LIVER OF PREGNANCY

• rare
• usually occurs in 3rd trimester of pregnancy or period immediately after delivery
  1. Features
  2. Investigations
  3. Management

Answer 1

1. Abdominal pain, nausea, vomiting, headache, jaundice, hypoglycaemia, may result in pre-eclampsia
2. Raised ALT ie 500 iu/L
3. Supportive care and delivery once stabilised

Question 2

INTRAHEPATIC CHOLESTASIS IN PREGNANCY/OBSTETRIC CHOLESTASIS

• Most common liver disease in pregnancy(1%)
• Usually occurs in 3rd trimester
  1. Features
  2. Management
  3. Complications

Answer 2

1. Pruritus, often in palms and soles. No rash. Raised bilirubin
2. Ursodeoxycholic acid for symptomatic relief. IOL at 37w.
3. Increased risk of stillbirth