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NICU Fellow > Jaundice > Flashcards

Jaundice Flashcards

1
Q

Bilirubin Metabolism

A

Heme: broken down to Fe and unconjugated bilirubin (lipid soluble)

Enzyme: UDP glucuronyltransferase adds glucuronic acid (water soluble)

Intestine: GI enzyme removes glucuronic acid to form urobilinogen (10% reuptake via portal vein)

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2
Q

Physiological Jaundice

A
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3
Q

Pathological Jaundice

INCREASED PRODUCTION

A
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4
Q

Pathological Jaundice

DECREASED CLEARANCE

A
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5
Q

Pathological Jaundice

INCREASED ENTEROHEPATIC CIRCULATION

A

Gilbert’s: mutation in UGT1a1 gene causing decreased activity UDP glucuronyltransferase enzyme

Crigler-Najjar: absence of UDP glucuronyltransferase

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6
Q

Jaundice

NEUROLOGIC SEQUELAE

A
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7
Q

Jaundice

TREATMENT

A

Blue light: 450-490nm

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8
Q
A
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NICU Fellow (9 decks)

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