Isosorbide mononitrate

Question 1

Isosorbide mononitrate Dosage?

Answer 1

• Initial 5-20mg daily 7hr apart

Question 2

Isosorbide mononitrate Class?

Answer 2

• Nitrate
• Antianginal

Question 3

Isosorbide mononitrate action?

Answer 3

-Interacts with nitrate receptors in vascular smooth muscle cell membranes
- An increased CGMP level relaxes vascular smooth muscle by forcing calcium out of the muscle cells causing vasodilation
- Improves cardiac output by reducing preload and afterload

Question 4

Isosorbide mononitrate Contraindications?

Answer 4

• Concurrent of phosphodiesterase inhibitors
• Hypersensitivity to it or other nitrates

Question 5

Isosorbide mononitrate Interactions?

Answer 5

• Alcohol use increases orthostatic hypotension
• vasodilators
  -phosphodiesterase inhibitors

Question 6

Isosorbide mononitrate education?

Answer 6

• teach pt how to recognize s/sx of angina
• do not crush or chew
• Educate about length of time if med is taken more than once a day
• notify provider if blurred vision, fainting, increased angina attacks
• avoid hazardous activities until CNS effects are known
• store drug in tightly closed container and protect from heat and light
• educate about orthostatic hypotension and changing positions slowly

Question 7

Isosorbide mononitrate use?

Answer 7

• management of angina pectoris

Question 8

Isosorbide mononitrate Complications?

Answer 8

• arrhythmia
• NVD
• Hemolytic anemia
• Blurred vision
  -Rash
• Headache, confusion