Irritable Bowel Syndrome

Question 1

What is the peak age group for IBS?

Answer 1

30-40

Question 2

What is visceral hypersensitivity related to?

Answer 2

IBS

Question 3

What are the two mechanisms in visceral hypersensitivity?

Answer 3

Peripheral sensitisation

Central sensitisation

Question 4

What visceral hypersensitivity mechanism involves increased sensitivity of spinal neurones?

Answer 4

Central sensitisation

Question 5

What visceral hypersensitivity involves inflammatory mediators up-regulating sensitvity of nociceptor terminals?

Answer 5

Peripheral sensitisation

Question 6

What are two changes to diet that can be made to help IVS?

Answer 6

Regular meal times, reduce fibre

Question 7

With IBS what drugs should be stopped?

Answer 7

Opiate analgesia

Question 8

What three classes of drugs could be given to help IBS?

Answer 8

1. Anti-diarrhoeals
2. Anti-spasmodics
3. Anti-depressants

Question 9

What can prolonged use of opiates lead to?

Answer 9

Opiate/narcotic bowel syndrome

Question 10

Name two anti-spasmodics?

Answer 10

Mebeverine

Hyoscine

Question 11

Name an anti-diarrhoeal?

Answer 11

Loperamide

Question 12

Name a tricyclic used as an anti-depressant?

Answer 12

Amitriptyline