GORD and Dysmotility Flashcards
What does an incompetent lower oesophageal sphincter, poor oesophageal clearance nad barrier function/visceral sensitivity cause?
GORD
What are heartburn. acid reflux, waterbrash, dysphagia and odynophagia symptoms of?
GORD
What are 4 investigations for GORD?
- Endoscopy
- Barium swallow
- Oesophageal manometry and pH studues
- Nuclear studies
What two carcinomas can result from GORD?
Oesophageal carcinoma
Oesophageal adenocarcinoma
What are the two pathogenetic steps between a normal oesophagus and an adenocarcinoma?
Oesophagitis and Barrett’s
What is the main type of drugs used for GORD?
Antacids
What is the one class of drugs to treat GORD - begins with H?
H2 antagonists
Name two H2 antagonists?
- Cimetidine
2. Ranitidine
Name two PPI?
Omeprazole
Lansoprazole
What is the name of the surgery for severe/unresponsive GORD?
Nissen fundoplication
What is an irreversible result of GORD, occurs in 10% of GORD patients and involves intestinal metaplasia?
Barrett’s oesophagus
What are 4 methods of dysplasia management?
- Optimise PPI dose
- Endoscopic mucosal resection
- Radiofrequency ablation (HALO)
- Argon
What are two types of hiatus hernia?
Sliding hiatus hernia
Paraoesophageal hiatus hernia
What is gastroparesis?
Delayed gastric emptying
What is one clinical symptom of gastroparesis?
Feeling of fullness