Iron metabolism Flashcards
Iron is an important cofactor for what
oxygen transport and electron transport chain
Main storage organ for iron
Liver
Heme iron comes from what sources
Animal sources
Which is better absorbed heme or non-heme iron
Heme iron
What are the sources of non heme iron
Plants
Iron is required most in who
Pregnant women
Non heme iron is reduced by what
Duodenal cytochrome B
Non-heme iron is imported through what to enter cell
DMT1
Non-heme iron is stored in
ferritin
One ferritin complex can store how much iron
about 4500
Heme iron is transported across the membrane by what
Heme carrier protein
Heme iron is stored in what within the cell
Ferritin
How is iron secreted from the body
ITS NOT SECRETED only regulated by absorption
What is the only known iron exporter from the cells
Ferroportin
Once iron leaves the cell its oxidized by what
Hephaestin
Iron is transported through the blood bound to what
Transferrin
Negative regulator of iron transport
Hepcidin (negative regulator)
What inhibits hepcidin
Erythroferrone (positive regulator)
Hepcidin is influenced by what
Inflammation and infection
Transferrin binds to what at a target tissue
Transferrin receptor
Best tests for iron levels
Serum ferritin & Transferrin saturation
Serum ferritin measures what
Iron storage status
Serum ferritin can be elevated by what
Inflammation or infection
When is it useful to measure the levels of soluble transferrin receptor
during inflammation
Low iron levels stimulates what
IRPs to bind IRE to increase levels of TfR
Hemochromatosis
Excessive absorption of iron from dietary sources
Hemochromatosis is from what
mutations in hepcidin, ferroportin, transferrin receptor (all negative regulators)
How to treat iron overload
Chelating agents and gastric lavage
