IR to microbes 2

Question 1

Th-17 activate………….. To kill fungal infection

Answer 1

Neutrophil

Question 2

Ir to fungal infection include_—_____-,____

Answer 2

Innate →neutrophils
Adaptive →.c.m.i.r→ killers
+th-17

Question 3

T h-17 deficiency cause______

Answer 3

Candidiasis

Question 4

Candidemia increase the risk of—– ______

Answer 4

Neutropenia

Question 5

Function of t-helper2 cells (i.r. To helminths)

Answer 5

B-cell+IL-4→production of IgE+neutralizing IgG AB
Eosinophil + IL-5→activation of eosinophil
Activated MQ + IL-10/ IL-4 →suppression of MQ activation

Question 6

mention Interleukin-4 function ?

Answer 6

Eosinophil production+ b-cell proliferation/differentiation + IgE switch +most cell/basophils activation

Question 7

CMI in response to helminthic parasites is mediated by…….. cells that stimulate the production of and…… activation of…………

Answer 7

TH2/IgE/eosinophils

Question 8

Microbial Evasion of IR?? First 3 ways

Answer 8

Ciliotoxic /Ciliostatic → Inhibit ciliary activity ex: Bordetella, Streptococcus,

IgA1 protease→ IgA is the primary antibody found on the mucosal surfaces ex: Pneumococci, H.influenza

Capsules » هنا الاننيت راحت فيها ex: Neisseria meningitidis, Haemophilus influenzae

Question 9

Mention the organism
• Inhibit chemotaxis

Answer 9

S pyogens C5 peptidase

Question 10

Mention the organism

Inhibit phagocytosis

Answer 10

S pneumoniae capsule

Question 11

Mention the organism

Inhibit opsonization

Answer 11

S aureus protein A

Question 12

Mention the organism

Kill phagocyte

Answer 12

(S aureus leucocidin)

Question 13

Mention the organism
Inhibit lysosomal fusion

Answer 13

M. tuberculosis

Question 14

Mention the organism
Escape lysosome and grow in cytoplasm

Answer 14

Listeria & salmonella

Question 15

Mention the organism

Block activation by IFN-gamma??

Answer 15

Mycobacteria

Question 16

Microbial Evasion of IR?? Last 3

Answer 16

Antigenic Variation » ex : HIV, HCV

Intracellular infection of immune cells→ Infection of B cells (EBV) + Infection of CD4 cells (HIV, HTLV-1)

Suppression of CMIR» ex: Measles virus, EBV

Question 17

Modulins !!!يخلي الاميون ريسبونس يأذي فقط الجسمAg هنا

Answer 17

HETEROPHIL ANTIGENS→ex : Rheumatic fever/ where the human myocardium shares epitopes with M protein present in the cell wall of streptococcus pyogens.

Damage to host cells by inflammatory
response

Endotoxin → lipopolysaccharide» fever +leukopenia +complement activation+DIC shock death

Superantigens »They non-specifically activate very large numbers of lymphocytes results in a release of large amount of cytokines, causing capillary leak syndrome, leading to shock.

Bacteriatl biofilms exopolysaccharide matrix ex : S.aureus, S.epidermidis infections of CVC