Abs

Question 1

Define antibodies

Answer 1

Glycoprotein found mainly in gamma-globulin fraction of serum

Question 2

The antibodies differs in the ——- chain and define the type of a.b

Answer 2

Heavy

Question 3

Ig allotypes→ these markers are on the…………. ab region with L or H and are…….…….. It is genetically different
allotypes are used fo………..testing

Answer 3

constant
Individual specific
Paternity

Question 4

Idiotypes
They lie in the……….ab region
its composed of a bunch of different………………

Answer 4

Variable / idiotopes for (epitope binding site)

Question 5

IgG (1,2,3,4)

IgG is …..% of total Ig pool (موجود بكل مكان “diffusible”)
Activities of IgG………….,…………,…………,…………,………..

Answer 5

70~75
Complent fixation , toxin neutralization, pass placenta(passive immunity (except IgG 2 )) , opsinization , ADCC , 2ry IR (memory )

Question 6

IgM (the largest & strongest)
it has … binding sites (non diffuse ) bcr /……IR / come from …… b-cells / stronger than …
Activity:

Answer 6

10 /primary/naive/ IgG

Ccp activation / doesn’t pass placenta (diagnosis of intra uterine inf &recent inf)
As AB against blood groups / bacteremia/ TI Ag

Question 7

IgD
Less than…% of total Abs

Answer 7

1

Question 8

IgA
It’s—-% of total abs /it mainly occur as …………
IgA can be inactivated by IgA protease by ……………. , ……………… , …………
IgA 2 is more imp in mucousal
Activity → gpa

Answer 8

15~20 / Monomer
Gonococci / pneumonococci / H influenza
Gate keeper / prevent » adherence + attachment +Auto immune + allergy

Question 9

IgE
Is not found in the blood but in the——-,——,———-
For- - - - - -infection /
action : homocytotropic /(ADCC) / HSR

Answer 9

Most cells esinophill basophill
Parasitic inf

Question 10

Monoclonal ab→…………………………………………….
Uses→————,—————-,—————,———-

Answer 10

Highly specific abs vs a single epitope
Diagnostic & lab / genetic engineering / therapeutic uses / immunization → passive(anti-venom, anti-rh, anti-toxin) + active (anti idiotopes vaccine )