Ipratropium Bromide

Question 1

Class

Answer 1

Anticholinergic

Bronchodilator

Question 2

Mech of action

Answer 2

Anti-cholinergic, parasympatholytic, agent appears to inhibit vaguely mediated reflexes by antagonizing the action of acetylcholine the transmitter released from the vagal nerve

Question 3

Indications

Answer 3

Treatment of bronchospasm associated with chronic obstructive pulmonary disease, emphysema and chronic bronchitis. To be use either alone or in combination with other bronchodilators especially beta adrenergics( albutrol)

Question 4

Adverse reaction

Answer 4

Coughing
Increase sputum
Dizziness
Insomnia
Tremors
Nervousness
Nausea

Question 5

Notes of admin

Answer 5

Is a safe and effective bronchodilator when used in conjunction with albuterol

Question 6

Adult

Ped

Answer 6

Give 500 µg in 2.5 mL NS (1 unit does vial) via SVN with the mouthpiece or in line with a ventilatory device. Repeat according to medical control preference. May mix one unit does vial of ipratropium bromide with one unit does vial of albutrol.

Same… Do not repeat

Question 7

Special notes

Answer 7

Anti-cholinergics produce preferential dilation of the larger central airways, in contrast to beta agonist, which affect the peripheral airways.
Maybe more effective used in combination with beta agonists.

Should be kept out of light and excessive humidity

Question 8

contraindications

Answer 8

Ipratropin bromide is contraindicated in known or suspected cases of hypersensitivity to ipratropium bromide or to atropine and its derivatives.

Caution: should be used with caution in patients with narrow angle Glaucoma

Question 9

Routes of administration

Onset of action

Peak effects

Duration of action

Drug box minimum supply

Answer 9

Nebulize, mouthpiece or in line
Inhaler (pts own)

5 to 15 minutes

60- 120 minutes

240 to 480 minutes

5 mL