Ion Flux Through Membranes Flashcards
1
Q
What are 2 examples of Primary Active Transporters?
A
Na/K ATPase
Ca ATPase
2
Q
What are examples of Secondary Active Symporters/Antiporters?
A
Symporter = Na/Glu Antiporter = Na/Ca
3
Q
How does a defective amino acid transporter lead to cystinuria?
A
Causes cystine crystals to build up in the kidney.
Identified via + nitroprusside test
4
Q
What is Hartnup Disease?
A
Defect in nonpolar/neutral amino acid transport
5
Q
What are the names of the Cardiotonic drugs and how do they function?
A
Names = Ouabain and Digoxin Function = inhibit Na/K ATPase --> increased intracellular Na --> increased intracellular Ca --> increased heart contraction
6
Q
What is the mechanism of action behind Cystic Fibrosis?
A
Mutation in CFTR gene causes defect in Cl transporter –> Cl build up in cells –> Na influx –> H2O influx –> decreased extracellular fluid
