Glucose Metabolism Flashcards
Explain hexokinase…
Glucose –> G6P (glycolysis)
*present in all cells
Explain glucokinase…
Glucose –> G6P (glycolysis)
*present in liver, low affinity and high capacity for glucose
Explain PFK1…
F6P –> F-1,6-BP (glycolysis)
*Committed step
Explain phosphoglycerate kinase…
1,3-BPG –> 3-PG (glycolysis)
*creates an ATP
Explain pyruvate kinase…
PEP –> pyruvate (glycolysis)
*creates an ATP
Where do galactose and fructose enter glycolysis?
Galactose = G6P
Fructose (dietary) = DHAP/GAP
Fructose (fat) = F6P
How is pyruvate kinase activated/inactivated?
Phosphorylation = inactivated Dephosphorylation = activated
Where does High-Fructose Corn Syrup enter glycolysis?
DHAP
Explain pyruvate carboxylase…
Pyruvate –> oxaloacetate (gluconeogenesis)
Explain PEP carboxykinase…
Oxaloacetate –> PEP (gluconeogenesis)
Explain F-1,6-BPase…
F-1,6-BP –> F6P (gluconeogenesis)
Explain G6Pase…
G6P –> Glucose (gluconeogenesis)
Explain G6P dehydrogenase…
G6P –> Ribulose-5-phosphate (pentose phosphate)
- Rate limiting and oxidative step
- Creates 2 NADPH
Explain phosphoglucomutase…
G6P –> G1P (glycogenesis)
Explain UDP-glucose pyrophosphorylase…
G1P + UDP –> UDP-glucose (glycogenesis)