Cell Membranes

Question 1

Which phospholipids are located on the extracellular side of the cellular membrane?

Answer 1

Phosphatidylcholine, glycolipids, sphingomyelin

Question 2

Which phospholipids are located on the intracellular side of the cellular membrane?

Answer 2

Phosphatidylserine, phosphatidylinositol, phosphatidylethanolamine

Question 3

What is Niemann-Pick disease?

Answer 3

Deficiency in sphingomyelinase (breaks down sphingomyelin)

Causes hepatosplenomegaly, neurologic damage, and “cherry red spots” in eyes

Question 4

Which antigen does the Rh factor apply to?

Answer 4

ONLY the D angiten

Question 5

How does temperature affect membrane fluidity?

Answer 5

Temp > Tm = optimal fluidity
Temp&raquo_space;> Tm = too fluid
Temp

Question 6

How do saturated VS unsaturated lipids affect membrane fluidity?

Answer 6

Saturated = decrease fluidity
Unsaturated = increase fluidity

Question 7

How does cholesterol affect membrane fluidity?

Answer 7

In rigid membranes = increases fluidity

In fluid membranes = decreases fluidity

Question 8

What is Spur Cell Anemia?

Answer 8

Increase in cholesterol in RBCs causing decreased fluidity and flexibility.
Causes RBCs to lyse as they move through capillaries in the spleen