Introduction to formulations Flashcards

1
Q

How do we classify dosage forms and give examples?

A
  • Based on route of administration or physical forms (e.g. solid, liquid and semi solid)
  • Oral, vaginal, transdermal, nasal
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2
Q

Factors to consider when a drug is being formulated

A
  • Target population (general, geriatric, paediatric, healthy, conscious?)
  • Route of administration
  • Formulation type, dose, regimen
  • Stability/Shelf life
  • Means of manufacture
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3
Q

Describe what occurs in the pre-formulation stage

A
  • Pre-formulation – investigation of key properties of the API
  • Formulation – means of delivering the API
    • Physico –chemical properties, e.g.:
  • Determination of molecular structure (Analytical techniques PM2PY3)
  • Crystal form – crystalline, amorphous; polymorphic form (Crystals Lectures)
  • Solubility (and dissolution) – all APIs must have (some) aqueous solubility for therapeutic effect
    (Liquid formulations, Prof Shankland’s Biopharm and Pharmacokinetics Lectures and others)
  • Stability (T°, humidity, oxygen, light)
  • Drug-additive interactions
  • Organoleptic properties (related to taste, smell, sight, touch)
  • Physico-mechanical properties:
  • Powder properties (Powders and Tablets Lectures)
  • particle size
  • surface area
  • powder flow and densities
  • compression properties
  • Wettability
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