Introduction to formulations Flashcards
1
Q
How do we classify dosage forms and give examples?
A
- Based on route of administration or physical forms (e.g. solid, liquid and semi solid)
- Oral, vaginal, transdermal, nasal
2
Q
Factors to consider when a drug is being formulated
A
- Target population (general, geriatric, paediatric, healthy, conscious?)
- Route of administration
- Formulation type, dose, regimen
- Stability/Shelf life
- Means of manufacture
3
Q
Describe what occurs in the pre-formulation stage
A
- Pre-formulation – investigation of key properties of the API
- Formulation – means of delivering the API
- Physico –chemical properties, e.g.:
- Determination of molecular structure (Analytical techniques PM2PY3)
- Crystal form – crystalline, amorphous; polymorphic form (Crystals Lectures)
- Solubility (and dissolution) – all APIs must have (some) aqueous solubility for therapeutic effect
(Liquid formulations, Prof Shankland’s Biopharm and Pharmacokinetics Lectures and others) - Stability (T°, humidity, oxygen, light)
- Drug-additive interactions
- Organoleptic properties (related to taste, smell, sight, touch)
- Physico-mechanical properties:
- Powder properties (Powders and Tablets Lectures)
- particle size
- surface area
- powder flow and densities
- compression properties
- Wettability