Drug Synthesis To The Lungs

Question 1

Define pharmacophore

Answer 1

Groups that are identified to be essential for pharmocological activity

Question 2

Name all the steps which lead to the synthesis of a drug

Answer 2

1. Identify the biological target e.g. for asthma B2 receptors
2. Then identify the lead compound e.g. we know adrenaline dilates airways, but it has short action so they switch up some functional groups
3. Then identify which functional groups are important - taking into account binding interactions, the pharmacophore
4. Selectivity of action - want b2 activation
5. **Duration of action and metabolic stability **
6. Stereochemistry - use single enantiomer rather than a range
7. Duration of action restricted - alter physiochemical properties