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Endocrine Lectures Important Points > Introduction to endocrine > Flashcards

Introduction to endocrine Flashcards

1
Q

How is specificity of signalling achieved?

A

Chemically distinct hormones
Specific receptors
Distinct distribution of receptors

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2
Q

What are 2 examples of amino acid hormones?

A

Adrenaline

Thyroid hormone

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3
Q

How are amino acid hormones made, stored and released?

A

Pre-synthesized
Stored in vesicles
Secreted in response to Ca2+ dependent exocytosis

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4
Q

Are amino acids hydrophillic or hydrophobic?

A

Hydrophyllic

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5
Q

What are all steroid hormones derived from?

A

Cholesterol

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6
Q

What are 3 examples of steroid hormone?

A

Cortisol
Testosterone
Progesterone

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7
Q

How are steroid hormones made, stored and released?

A

Synthesized and secreted on demand

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8
Q

T/F only biologically active steroids can cross the capillary wall?

A

True

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9
Q

What are 3 examples of peptide hormones?

A

ACTH
ADH
Oxytocin

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10
Q

How are peptide hormones made, stored and released?

A

Pre-synthesised
Stored in vesicles
Released in response to Ca2+ dependent exocytosis

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11
Q

What is an example of a protein hormone?

A

Insulin

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12
Q

How are protein hormones made and stored?

A

Pre-synthesized from longer precursors

Stored in vesicles

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13
Q

How is plasma concentration calculated?

A

PC= Rate of secretion - rate of elimination

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14
Q

How many classes of nuclear receptor are there?

A

3

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15
Q

What activates class 1 nuclear receptors?

A

Steroids

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16
Q

Where are class 1 nuclear receptors found?

A

Cytoplasm

Bound to HSPs

17
Q

What activates class 2 nuclear receptor?

A

Activated by lipids

18
Q

Where are class 2 nuclear receptors found?

A

Nucleus

19
Q

What activates hybrid nuclear receptors?

A

Thyroid hormone and others

20
Q

What activates GCPR?

A

Amines

Proteins and peptides

21
Q

What activates receptor kinases?

A

Proteins and peptides

22
Q

What kind of response occurs when a hormone binds to its cognate receptor?

A

Biological

Endocrine Lectures Important Points (5 decks)

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