Introduction of Pharmacokinetics Flashcards
1
Q
What is the aim of drugs
A
For drug concentration to be in between effective concentration and toxic concentration
2
Q
What determines plasma concentration of drug
A
Absorption which depends on route of admin, blood flow at site of admin, drug solubility
Distribution which depends on blood flow, lipid solubility, tissue binding, protein binding
Metabolism
Exretion
3
Q
Why does little drug make it to site if orally administered
A
Metabolised in liver and tissues
4
Q
What does dose interval depend on
A
Plasma half life
