Introduction Flashcards

1
Q

what is pathophysiology

A

the study of the underlying changes in body physiology (molecular, cellular, and organ systems) that result from disease or injury

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2
Q

What is disease?

A

An acute or chronic illness that one acquires or is born with that causes physiological dysfunction

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3
Q

what is illness?

A

a persons experience of a disease

a state where a person has feelings or pain or discomfort that does not have an identifiable reason

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4
Q

what is etiology?

A

the study of the cause of disease

ex, AIDs is caused by HIV

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5
Q

what is epidemiology?

A

the study of patterns of disease in large groups of people

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6
Q

What are the two terms included in epidemiology?

A

incidence and prevalence

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7
Q

what is incidence?

A

the number of new cases during a specific time (typically a year)

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8
Q

what is prevalence?

A

existing disease at any given time (total)

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9
Q

what is primary prevention?

A

-prevent disease from occurring

ex, education, physical activity, genetic testing, good hygiene, not smoking, vaccinations

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10
Q

what is secondary prevention?

A

Early detection of disease

ex, screening, pap smears, testicular exams

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11
Q

what is tertiary prevention?

A

Prevent deterioration/ complications
early aggressive treatment
disease is already present
rehab

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12
Q

risk factors can either be..

A

non-modifiable or modifiable

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13
Q

what are non modifiable risk factors and what are some examples?

A

def: can either directly cause (etiology) or increase our risk of disease
- ex, heredity, genetics, age (susceptibility of disease and cancer increases with ag) , sex, ethnicity (leukemia is higher in Caucasian people, high bp is more common in ethnic groups)

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14
Q

What are some examples of modifiable risk factors?

A

smoking, alcohol and drug use, level of activity/ immobility, body weight, diet/ nutrition, environment, social determinants of health, and stress

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15
Q

what is “intrinsic” cause?

A

within is as a whole organism, genetics, inflammatory system, nervous system

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16
Q

what is extrinsic cause?

A

outside of organism- ex, virus, infection

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17
Q

what is idiopathic cause?

A

unknown process

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18
Q

what is iatrogenic cause?

A

related to medical care, ex- catheter can cause UTI

19
Q

the process of disease can be related to…

A
multifactorial (many factors contributing to disease) obstruction 
genetics 
inappropriate inflammatory response
inappropriate immune response 
infection 
inappropriate cellular environment 
(neutransmitters, fluids, electrolytes, acid/base
inappropriate cell growth
20
Q

what are multifactorial disorders?

A

Diseases caused by a number of genes acting together and influenced by other factors
ex, genetics +inflammation / immune / infection

21
Q

what is obstruction?

A

an obstruction that can occur anywhere their is a “tube”

ex, reproductive, gastrointestinal, respiratory, cardiovascular, vein, blood vessles, kidneys, brain

22
Q

what are the two types of obstruction?

A

1) mechanical

2) functional

23
Q

what is mechanical obstruction?

A

a physical object that blocks a tube

ex, tumor, blood clot, kidney stone

24
Q

what is functional obstruction?

A

ex, paralysis, impaired function, paralysed renal system

25
Q

how can genetics cause disease?

A

mutations, aneuploidy, single gene disorders

26
Q

what is a mutation?

A

any inherited alteration of genetic material

27
Q

what are mutagens?

A

radiation, various chemicals

28
Q

what is base pair substitution?

A

when one base pair is substituted for another

29
Q

what is frameshift mutation?

A

addition or deletion of one base pair

30
Q

what is aneuploidy?

A

an abnormal number of chromosomes

normally: have 23 pairs of chromosomes (46 total)
- some ppl end up with one missing or one extra, due to non-disjunction

31
Q

where can non-disjunction be located?

A

meiosis 1 or meiosis 2

32
Q

what is monosomy?

A

turners syndrome, the only one that is survivable ( a single Y chromosome cant survive, not enough genetic info)

33
Q

how many X chromosomes in turners syndrome (monosomy)

A

one single X chromosome

34
Q

what are the characteristics of someone with turners syndrome?

A
webbed fingers and toes
wide hips 
short 
normal intelligence 
cardiac malformation in aorta
35
Q

what is an example of Trisomy?

A

Klinefelter syndrome

36
Q

what X or Y chromosomes are in Klinefelter’s?

A

XXY

37
Q

what are the characteristics of someone with Klinefelter’s

A
taller than average 
female characteristics, male looking 
breats
wider hips 
less facial hair 
less body hair 
small testes
38
Q

what trisomy 21?

A

Down syndrome

39
Q

Characteristics of a person with down syndrome?

A

large tongue
distinctive eyes
low ears

40
Q

what are single gene disorders caused by?

A

cause by a single gene that is defective or mutated

41
Q

what is autosomal recessive single gene disorder?

A

When both parents have a recessive gene for the disease- so the offspring will have
25% to be normal
50% carriers
25% will have the disease

42
Q

what is autosomal dominant single gene disorder?

A

only one dominant gene needs to be present for the disease to occur
50% will be normal
50% will have disease

43
Q

what is X-linked single gene disorder?

A

a disease that is on the X chromosome
-males will inherit these types of diseases from thier mother, because they dont have a normal X to counteract
Females will become carriers
-inherit an abnormal X but also inherit a normal X from father