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PHARMACOLOGY > INTRO TO THE AUTONOMIC SYSTEM > Flashcards

INTRO TO THE AUTONOMIC SYSTEM Flashcards

1
Q

TYPE OF ANS FIBERS

from visceral structures
1st link in reflex arcs of ANS (visceral pain or vessel stretch)
asstd with chronic pain management

A

afferent fibers

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2
Q

TYPE OF ANS FIBERS

accompanied by sensory fibers

A

efferent fibers

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3
Q

Autonomic N.S.

interruption of transmission –> __________

A

spontaneous activity

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4
Q

somatic n.s.

interruption of impulses —-> ___________

A

paralysis and atrophy

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5
Q

principal site of ANS organization

A

hypothalamus

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6
Q

Hypothalamus

function of:
Ant. Hypothalamus - ________
supraoptic hypothalamic nuclei - ___________

A

temperature regulation
water metabolism regulation

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7
Q

SNS has a _______ physiologic response (mass reflex)

A

diffuse

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8
Q

unpaired collateral ganglia

C
S
I

A

celiac ganglia
superior mesenteric ganglia
inferior mesenteric ganglia

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9
Q

sympathetic: adrenoreceptors

A

alpha
beta

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10
Q

parasympathetic: cholinoreceptors

A

muscarinic
nicotinic

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11
Q

CHOLINERGIC NERVE TERMINALS

SYNTHESIS AND STORAGE

the rate limiting step is probably the transport of choline into the nerve terminal.

this transport can be inhibited by the research drug ________

A

hemicholinium

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12
Q

CHOLINERGIC NERVE TERMINALS

SYNTHESIS AND STORAGE

ACTH is actively transported into its vesicles for storage by this vesicle associated transporter VAT

this process can be inhibited by another research drug, _________

A

Vesamicol

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13
Q

CHOLINERGIC NERVE TERMINALS

RELEASE OF ACTH

several types of _______ are able to enter cholinergic nerve terminals and enzymatically alter synaptobrevin or one of the other docking or fusion proteins to prevent the release process

A

botulinum toxin

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14
Q

ADRENERGIC TRANSMISSION

SYNTHESIS AND STORAGE:

tyrosine hydroxylase can be inhibited by _________

A

metyrosine

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15
Q

ADRENERGIC TRANSMISSION

SYNTHESIS AND STORAGE:

VMAT can be inhibited by _________ resulting in depletion of transmitter stores

A

reserpine

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16
Q

ADRENERGIC TRANSMISSION

SYNTHESIS AND STORAGE:

drugs that inhibit the distabilization of the wall of the vesicle

A

guanethidine

17
Q

ADRENERGIC TRANSMISSION

SYNTHESIS AND STORAGE:

drugs that inhibit the norepinephrine transporter NET

A

cocaine
TCA

18
Q

cell surface receptors that detect molecules outside the cell and activate cellular responses

heterotrimer: a, b, y subunits
classified based on distinctive alpha subunits

A

G PROTEINS

19
Q

g proteins classified:

——— - stimulatory G protein of adenylase cyclase

___________ - inhibitory G proteins of adenylase cyclase

__________ - G proteins coupling alpha receptors to phospholipase C

A
  1. Gs
  2. Gi and Go
  3. Gq, and G11
20
Q

____________ a subunit regulates activity of its effector (adenyl cyclase, cGMP, phosphodiesterase, phospholipase channels)

A

activated GTP

21
Q

Alpha 1 Receptors decreases _______ and _______

A

IP3 and DAG

22
Q

Alpha 2 receptors decreases

A

CAMP

23
Q

B1, B2, B3 increases ___________

A

increases CAMP

24
Q

D1 increases ________

A

CAMP
G protein

25
Q

parasympathetic agonists
choline esters

A,M,C,B

A

ACTH
Metacholine
carbachol
betanechol

26
Q

parasympathetic agonists
DIRECT ACTING choline esters

opthalmology: 1% drops of rapid meiosis

minimal dose: vasodilation, decrease BP , reflex increase in HR

A

ACTH

27
Q

parasympathetic agonists
DIRECT ACTING choline esters

mainly muscarinic activity
selective for GIT and GUT

A

BETANECHOL

28
Q

parasympathetic agonists
DIRECT ACTING choline esters

mainly muscarinic activity
slows the heart and dilates peripheral BV
terminate SV tachyarrhythmias
increases intestinal tone

A

metacholine

29
Q

drugs for organophosphate poisoning includes

A
P
D

A

atropine
pralidoxime
diacetylmonoxime

30
Q

parasympathetic antagonists

premedication: mild cns stimulation
high doses: restlessness. disorientation, hallucinations, and delirium
avoid in tachycardic states

A

atropine

31
Q

specifically act on nicotinic receptors

no selectivity towards PNS or SNS
blocks entire ANS output

non depolarizing, competitive antagonists except nicotine

A

ganglionic blockers

32
Q
A

PHARMACOLOGY (5 decks)

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