GENERAL PRINCIPLES

Question 1

Absorption

All antacids binds with drugs to reduce absorption/ increase intragastric pH (altering drugs solubulity; do not give within 2 hours of doses

T,F,I,I

Answer 1

tetracyclines
fluoroquinolones
itraconazole
iron

Question 1

Routes of drug administration
enteral - ________
parenteral - ________
topical- __________

Answer 1

oral rectal

IV, IM, SC, intraperitoneal, intrathecal intra arterial

inhalation, optic, otic

Question 2

site of administration to site of action

Answer 2

distribution

Question 3

how a drug transverses the plasma membrane
examples are aqueous diffusion, lipid diffusion, special carriers, and endocytosis

Answer 3

permeation

Question 4

_______ of drugs may markedly reduce their ability to permeate membranes

Answer 4

ionization

Question 5

neutral molecule that can reversibly dissociate into an anion and proton

Answer 5

weak acid

Question 6

DIstribution
factors affecting protein binding include:

A.Alpha.C,B

Answer 6

albumin concentration
alpha 1 acid glycoprotein
capacity limited
binding to RBCs

Question 7

2PHASES

Phase __ - introduce or unmask a functional group

example: dealkylation, oxidation, reduction, hydrolysis, deamination, cytochrome p450

Answer 7

phase1

Question 8

study of substances that interact with living system to produce an effect

Answer 8

pharmacology

Question 9

undesirable effects of chemicals on living systems

Answer 9

toxicology

Question 10

health economics
cost effect

Answer 10

pharmacoeconomics