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PHARMACOLOGY > AUTACOIDS > Flashcards

AUTACOIDS Flashcards

1
Q

drugs with important actions on smooth msucle

A

autacoids

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2
Q

Autacoids include:

H,S,V,M

A

histamine
serotonin
vasoactive peptides
membrane phospholipids

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3
Q

________- are derived from plants as well as in animal tissues and a component of some venoms and stinging secretions

A

histamine

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4
Q

histamine is formed by decarboxylation of the amino acid _______, a reaction catalyzed by the enzyme _______

A

L-histidine
Pyridoxal PO4 dependent L-Histidine Decarboxylase

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5
Q

most tissue histamine is sequestered and bound in (vesicles) in __________

A

mast cells

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6
Q

2 pathways of histamine metabolism

D,M

A

deamination
methylation

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7
Q

deamination of histamine

small intestine, liver, kidney, and monocytes
_____ by 9-11%

A

imidazole acetic acid

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8
Q

methylation of histamine

small intestine, liver, skin, kidney, thymus, and leukocytes
______ by 42-47%

principal urinary metabolite
______ by 4-8%
_______by 2-3%

A

imidazole acetic acid

n-methylhistamine
histamine

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9
Q

4 HISTAMINE RECEPTORS

predominant in endotracheal and smooth muscle

A

H1

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10
Q

4 HISTAMINE RECEPTORS

Facial veins, carotid art., pulmonary art., heart, gastric mucosa, smooth muscle and some immune cells

A

H2

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11
Q

4 HISTAMINE RECEPTORS

several areas in CNS
decreases transmitter release from histaminergic and other neurons
presynaptic

A

H3

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12
Q

4 HISTAMINE RECEPTORS

eosinophils, neutrophils CD4 T Cells, inflammation and allergy

A

H4

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13
Q

3 STAGES of TRIPPLE RESPONSE

A

red spot
flare response
edema

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14
Q

Histamine antagonists

Physiological: __________
Release Inhibitors which reduces mast cell degranulation: _______
Histamine Receptor Antagonists: ________

A

epinephrine
Cromolyn Na, Nedocromil

H1 receptor antagonists
H2 receptor antagonists for peptic disorder
burimamide

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15
Q

H1 RECEPTOR ANTAGONISTS: PHARMACOKINETICS

well absorbed from GIT (oral)
onset 30 minutes
duration 4-6 hrs

A

1st generation agents

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16
Q
A

PHARMACOLOGY (5 decks)

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