Intro to Pediatrics - Block 4 Flashcards
What are the classifications of a pre-term vs term newborn?
Pre-term: <37 weeks
Term: >37 weeks
Classifications of neonates?
Birth - 1 month
Classification of Infant?
1 month - 2 yr
Classifications of a child?
2-12 YO
Classification of adolescent?
12-18 YO
Growth charts used from birth to 36 months?
- Length
- Weight
- Head circumference
Growth charts use for 2-20 YO?
- Height
- Weight
- BMI
Describe the development of neonates and how they get older?
- Babies would lose water weight within the first 7 days of life do to stress and adjustment.
- Birth weight is regained by 10 days, however, if 10% of birth weight that is an indication for dehydration or malnutrition
- Babies have a lot of water and as they age they gain more protein and fat
How do vitals differ in neonates than infants and adolescents?
HR: generally higher
RR: generally higher
BP: generally lower
What is the difference between PK and PD?
PK: what the body does to the drug (ADME)
PD: What the drug does to the body (Ligand, receptor, tissue)
How does the PK change in pediatrics?
ADME varies by age even when normalized by body weight
How does PD change in pediatrics?
Differences receptor sensitivity and density
PO factors that impact absorption?
- Gastric pH
- Gastric motility
- Bowel length and absorptve area
- Enzymes and bile salts
- Microbial flora
GI/PO factors that impact absorption in neonates?
Gastric motility and emptying: reduced gastric emptying and poorly coordinated intestinal cotractility
* Adult pattern onset at 6-8 months
* Drug absorption is dependent on disintegration, dissolution, and formulation
Intestinal drug-metaolizing enzymes: Lower
Biliary function and pancreatic enzymes (amylase and lipase): Underdevelopment affects ability to solubilize lipophilic drugs
Gastric factors that impact absorption in neonates?
Neonates have higher gastric pH:
* Acid labile drugs are less broken down -> increased F
* Weak acids are neutralized -> decreased bioavailability
Gastric pH will decrease at age 2
Rectal factors that impact absorption in neonates?
Increased pulsatile contractions -> decreased holding time