intro to neuroscience Flashcards

1
Q

CT

A

method of 2D/3D imaging measuring the X-ray attenuation through a tissue

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2
Q

Magnetic Resonance Imaging (MRI)

A

2D/3D imaging by detecting signals produced by protons in water and fat molecules

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3
Q

T2 MRI

A

signal intensity related to water content (signal intensity increases with increased water content)

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4
Q

T1 MRI

A

signal intensity related to the differences in white and grey matter (they have different cellular structure)

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5
Q

Diffusion-weighted MRI

A

microscopic diffusion of water molecules is measured (in a specific direction)

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6
Q

PET

A

2D imaging based on detecting gamma rays produced by injected radiopharmaceutical

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7
Q

Radiopharmaceutical

A

molecule (given either intravenously or orally) with a radioisotope attached

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8
Q

what makes humans dominant species in comparison to other primates?

A

greatly developed frontal lobe

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9
Q

describe the relationship between grey mass and number of neurons in the cerebral cortex for humans?

A

many more neurons per grey mass

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10
Q

what is the encephalocentric theory?

A

theory the brain is the centre of sensation and understanding

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11
Q

what is the cardiocentric theory?

A

theory that the heart is the centre of sensations and intelligence

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12
Q

what is the dura and what is its function?

A

bag surrounding the brain that contains the CSF and brain: acts as a conduit for clearing out toxins, provides nutrients to the brain, mechanically acts as a cushion

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13
Q

what cells make up the grey matter?

A
  • glia
  • astrocytes
  • neurons
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14
Q

what structures are involved in a typical brain cell?

A
  • cell body
  • axons
  • dendrites
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15
Q

what is the function of dendrites?

A

receives signals from other neurons

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16
Q

what is the function of the axon?

A

axons transmit the processed signal in the cell body

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17
Q

brain structure of functional localisation

A

primary somatosensory cortex

18
Q

phineas gage (significant frontal lobe damage)

A
  • personality changes
  • fitful
  • irreverent
  • impatient
19
Q

monsieur loborgne (lesion in broca’s area)

A
  • only able to utter syllable: Tan Tan

- broca’s area identified to be responsible for speech

20
Q

glioblastoma

A

highly infiltrative brain tumour

21
Q

how does a CT scan work?

A
  • x-ray tube rotates around the patient
  • x-rays beamed through the patient
  • detectors detect the x-rays on the other side
  • measure the attenuation of the x-rays to lots of different tissues
22
Q

how can MRI be used to measure anatomical changes?

A
  • grey and white matter proportions
  • degenerative change
  • developmental abnormalities
  • disease-specific changes
23
Q

what is the difference between white and grey matter?

A

grey matter: inter and intra-cellular compartments have free motion
white matter: 50% of tissue volume is myelin structures

24
Q

difference in T1 of white matter and grey matter?

A

T1 of WM>GM

25
Q

How does T2 weighted MRI work?

A
  • H+ atoms in HO have one proton
  • the nucleus is positively charged (spins and acts as a magnet)
  • this spin generates a signal because the radio frequency interacts with protons
  • signal picked up by radiofrequency coils, computer processing produces an image
  • therefore more water= stronger signal and structural changes in the tissue are picked up
26
Q

what is white matter?

A

wiring between the grey matter

27
Q

what is the purpose of the myelin sheath?

A

enables electrical signals to progress from one part to the other

28
Q

what happens in MS?

A

myelination is lost

29
Q

what does a bright signal mean?

A

brighter the signal, more anisotropy (shows where the white matter tracts are)

30
Q

what does a diffusion tensor MRI show?

A

coloured lines show the direction and connectivity of the corticospinal tract coming up to the core of the brain- powerful tool for understanding degenerative disease

31
Q

explain the difference between signal intensity in arterial and venous blood in the brain?

A
  • arterial blood has a uniform magnetic field
  • increased glucose and oxygen extraction leads to increased blood flow
  • Oxy-Hb moves from arterial to venous, due to inc blood flow
  • Oxygen is released in the brain and so left with deoxy-Hb in the venous circulation which is paramagnetic
  • presence of paramagnetic deoxy-Hb causes a non-uniform magnetic field
  • therefore there is a reduction in signal intensity
  • veins have a lower signal intensity than the arteries
32
Q

how does a BOLD fMRI work?

A

blood-oxygen-level-dependent imaging: based on differing signal intensities in venous and arterial

33
Q

gross structural and pathological change

A

CT, MRI

34
Q

anatomical and developmental change

A

MRI

35
Q

metabolite levels

A

MRS

36
Q

blood flow

A

CT, PET, MRI

37
Q

metabolism

A

PET

38
Q

connectivity

A

MRI

39
Q

functionality

A

MRI, PET

40
Q

receptors

A

PET