Intro to immune (lecture 6 just now doing the intro woo) Flashcards
IL-7
common lymphoid progenitor signal
pro b and t cells are generated in the
bone marrow
digeorge syndrome
thymic hypoplasia or aplasia
hypoparathyroidism
congenital cardiac malformation
degree of immunodeficiency varies on thymus loss
deletion syndrome of 22q11.21 through .23
mature naive lymphocytes reside in
the circulation and peripheral lymphoid organs until activated by 1)APCs (t cells) or soluble Ag (b cells)
humoral immunity
adaptive defense against EC pathogens
Ab mediated - B cells/ Plasma cells
infant recieves ____ Ab from mom through breastmilk
IgA
fetus recieves _____ Ab from mom during pregnancy through circulation
IgG
cell mediated immunity
adaptive against IC pathogens
T cells and macrophages
cd8+ t cells function
kill infected cells (IC defense)
Ag-specific, MHC restricted
excrete granules at target cell - perforin/granzyme b enter cell and activate apoptotic pathways
cd4+ t cell function
cytokine secretion to activate macrophages to kill ingested microbes/ inflammation to kill microbers
th1 cell
secrete IFN-gamma
activate macrophages and induce IgG production
defense against IC
involved in autoimmune diseases/ tissues damage of chronic infections
th2 cell
secrete IL-4, IL-5, IL-13
activate mast cells, eosinophil, induce IgE production, alternative macrophage activation
defense against helminith parasites
involved in allergic diseases
th17 cell
secrete IL-17A,F, IL-22
activate neutrophilic, monocytic inflammation
defense against EC bacteria, fungi
involved in autoimmune inflammatory disease
IL-12
induces differentiation of t cells to th1 cells
passive immunization
intro of Ab or antiserum into naive recipient (does not challenge recipient immune system)
