Intro to CV pharm

Question 1

What are the 2 divisions of the ANS ad how are they divided?

Answer 1

1. Sympathetic (thoracolumbar)

2. Parasympathetic (craniosacral)

Question 2

Where do both divisions originate from?

Answer 2

Both divisions originate in nuclei within the CNS and give rise to preganglionic efferent fibers that exit from thebrain stem or spinal cord and terminate in motor ganglia.

Question 3

Where do sympathetic preganglionic fibers exit the CNS?

Answer 3

Through the thoracic and lumbar spinal nerves

Question 4

Where do parasympathetic preganglionic fibers leave the CNS?

Answer 4

Through the cranial nerves (particularly 3, 7, 9, 10) and the 3rd and 4th sacral spinal nerves

Question 5

What is the main side effect of Alpha-1 agonist?

Answer 5

Orthostatic hypotension and

syncope, especially on 1st dose

Question 6

What do Alpha-1 agonist do?

Answer 6

Block α1 receptors on arterioles and venules