Beta Blockers

Question 1

Which Beta Blockers show Membrane Stabilizing activity?

Answer 1

Propranolol, Acebutolol, and Carvedilol

Question 2

How do the Beta Blockers with MSA have their effect?

Answer 2

They Bind to Fast Na+ channels responsible for rapid depolarization (STAGE 0), Changing the rate of depolarization thus changing the rate of cardiac action potentials

Question 3

Which of the Beta Blockers have intrinsic sympathomimetic activity?

Answer 3

Pindolol, acebutolol, Carteolol, Labetalol

Question 4

What does ISA mean?

Answer 4

May activate some receptors partially in the absence of Catecholamines

Question 5

When would a beta blocker with ISA be appropriate?

Answer 5

When the patient suffers from Bradychardia

Question 6

Which Beta Blockers have Nitric Oxide producing properties?

Answer 6

Carteolol and Nebivolol

Question 7

Which Beta Blocker has Beta-2 receptor Agonism?

Answer 7

Carteolol

Question 8

Which Beta Blockers have Alpha-1 receptor antagonism and would protect against the vasonconstriction which brings about the reflex rise in BP after BB administration?

Answer 8

Labetolol, and Carvedilol

Question 9

Which Beta Blocker has Ca2t entry Blockade?

Answer 9

Carvedilol and Betaxolol

Question 10

Which Beta Blocker has Antioxidant properties?

Answer 10

Carvedilol

Question 11

Which BB is most effective in Patients with High Renin?

Answer 11

Propranolol

Question 12

Which BB is most effective in patients with little to no effect on plasma renin?

Answer 12

Pindolol

Question 13

What are the adverse effects of BB?

Answer 13

1. CHF is susceptible patients
2. Bradycardia, Bradyarrythmias in pts with Partial or complete AV conduction
3. Cold extremities
4. Abrupt discontinuation after long term use can exacerbate angina and increase risk of sudden death

Question 14

Which Patients should not receive BB? Especially Non-specific

Answer 14

Patients with COPD, and Asthma (Bronchospastic disease) due to the possible blockage of B-2 receptors which are needed for Bronchodilation

Question 15

What are the effects of BB on lipid profiles?

Answer 15

1. Little or no effect on total cholesterol or LDL
2. Increase triglycerides
3. Decrease Plasma HDLs

Question 16

Which BB seem to have less effect on Triglycerides and HDLs?

Answer 16

Those with ISA and Cardiac selectivity separately Those with Both i.e Acebutolol tend to reduce Choleterol and LDL