Intro.

Question 1

what functions are eosinophils involved in?

Answer 1

> allergy

> parasites

Question 2

what regulates platelet production?

Answer 2

thrombopoietin by mass feedback

Question 3

what is the lifespan of a platelet?

Answer 3

7 days

Question 4

what produces erythropoietin?

Answer 4

kidneys (in response to hypoxia)

Question 5

what is the function of erythropoietin?

Answer 5

it is an enzyme that stimulates stem cells to become red blood cells

Question 6

what is the reticulocyte count a measure of?

Answer 6

red cell production

Question 7

what do neutrophils do?

Answer 7

ingest and destroy pathogens (bacteria and fungi)

Question 8

what regulates neutrophils?

Answer 8

> IL-17

> macrophages

Question 9

what is the lifespan of a neutrophil?

Answer 9

1-2 days

Question 10

what is the function of a monocyte?

Answer 10

ingest and destroy pathogens (bacteria and fungi)

Question 11

subset monocytes migrate into the tissue and become what?

Answer 11

macrophages

Question 12

what cell produce antibodies?

Answer 12

b cell lymphocyte

Question 13

what is positive lymphocyte selection in the bone marrow?

Answer 13

gene rearrangements create functional receptor so the cell survives

Question 14

what is negative lymphocyte selection in the bone marrow?

Answer 14

if receptor recognises self antigens then it is triggered to die

Question 15

what is in the red pulp of the spleen?

Answer 15

red cells

Question 16

what is in the white pulp of the spleen?

Answer 16

immune function

Question 17

what infections can cause hypersplenism?

Answer 17

> CMV
> EBV
> TB
> Brucella
> malaria
> schistosomiasis
> leishmaniasis

Question 18

what haemolytic disorders can cause splenomegaly?

Answer 18

> thalassaemia
hereditary spherocytosis
autoimmune
megaloblastic anaemia

Question 19

what connective tissue disorders can cause splenomegaly?

Answer 19

> felty syndrome

> systemic lupus erythematous